功能裂隙灯生物显微镜对正常成人结膜微血管血流动力学指标的检测和临床应用价值

摘要

目的 探讨功能裂隙灯生物显微镜(functional slit lamp biomicroscopy,FSLB)对正常成人结膜微血管血流动力学指标的检测和临床应用价值.方法 随机抽取南昌大学医学院和中山眼科中心硕士研究生16人,其中男8人,女8人;年龄21～ 25岁.应用FSLB并使用软件程序(BenoitTM,TruSoft Inc,St.Petersburg,FL,USA)对受试者结膜微血管密度、微血管长度、微血管直径、微动脉血流速度、微静脉血流速度等指标进行检测,并分析受试者各指标特征.结果 受试者右眼微血管密度、长度、直径、微动脉血流速度、微静脉血流速度上方和下方、鼻侧和颞侧差异均无统计学意义(均为P＞0.05);受试者右眼微血管密度、长度、直径上方、下方均较鼻侧、颞侧减小,差异均有统计学意义(均为P＜0.05);受试者微动脉血流速度、微静脉血流速度右眼上方、下方均较鼻侧、颞侧明显增加,差异均有统计学意义(均为P＜0.05).左眼以及总眼数的情况和右眼相一致.结论 利用FSLB可以较为清晰地获得正常成人结膜微血管血流动力学指标,有很好的临床价值.%Objeetive To investigate the detection of hemodynamiCS parameters of conjunctival microvessels by functional slit lamp biomicroscopy (FSLB) in normal adult and its clinical application values.Methods Randomly selected 16 postgraduate students aged 21 to 25 years from the Nanchang University and Zhongshan Ophthalmic Center,including 8 males and 8 females.The density,length and diameter of conjunctival microvessel and the flow velocity of arteriolar and venular blood were measured by FSLB and software program (BenoitTM,TruSoft Inc,St.Petersburg,FL,USA),as well as the indicators' characteristics of the subjects' were analyzed.Results As for subjects' right eyes,the microvascular density,length,diameter,and the arteriolar and venular blood flow velocity were no significant difference between the upper,and lower sides,as well as between nasal and temporal sides (all P ＞ 0.05);meanwhile the microvascular density,length and diameter of the upper and lower sides were both lower than those of the nasal and temporal sides,and the differences were statistically significant (all P ＜ 0.05),while the arteriolar and venular blood flow velocity of the upper and lower sides were both significantly higher than those of the nasal and temporal sides,and the differences were statistically significant (all P ＜ 0.05).In addition,the changes in hemodynamics parameters of conjunctival microvessels of the left eyes and total eyes in subjects were consistent with the right eyes.Conclusion FSLB can clearly obtain hemodynamics parameters of conjunctival microvessels in healthy grown-ups,and has a promising clinical value.