环孢素A在非感染性葡萄膜炎治疗中的应用

摘要

Uveitis is a kind of refractory blinding eye diseases.Noninfectious uveitis is an important part of uveitis,which is thought to be an autoimmune disease,and systemic immunosuppressive therapy is usually required to prevent visual loss.As a selective T-cell inhibitor,cyclosporine A is one of the most widely used immunosuppressants,and has obvious therapeutic effect on many kinds of uveitis.Cyclosporine A combined with glucocorticoid,other immunosuppressants or biological agents can improve the therapeutic effect and reduce the side effects.Recently,the inhibitory effect on glucocorticoid-resistant Th17 cells and topical application of cyclosporine A,show its advantage and potential in the treatment of noninfectious uveitis.%葡萄膜炎是一种难治的致盲性眼病.其中,非感染性葡萄膜炎是一种自身免疫性疾病,通常需要全身行免疫抑制治疗来防止视力丧失.环孢素A是一种选择性T细胞抑制剂,为临床应用较多的免疫抑制剂之一,对多种葡萄膜炎有明显的治疗效果.环孢素A与糖皮质激素、其他免疫抑制剂或生物制剂联合应用,可在提高治疗效果的同时减少副作用.近年来,关于环孢素A对糖皮质激素抵抗型细胞的抑制作用及环孢素A局部应用的研究显示出其在非感染性葡萄膜炎治疗中的优势及潜力.