Objective To investigate the relationship between mean platelet volume (MPV) and diabetic macular edema (DME) in type 2 diabetic patients.Methods The study included 4 patient groups:40 healthy control as group 1,40 diabetic patients without diabetic retinopathy(DR) as group 2,40 DR patients without DME as group 3,and 40 DR patients with DME as group 4.Then the collection of general information,fundus photograph and OCT were conducted for the measurement and comparison of serum levels of platelet parameters including platelet count (PLT),MPV,platelet distribution width (PDW) and plateletcrit (PCT).Results Significant differences were found in MPV and PDW among the four groups (all P ＜ 0.05),but there was no significant difference in PLT and PCT levels (all P ＜ 0.05).Furthermore,MPV and PDW level was (11.07 ± 1.06)fL and (13.57 ±2.25)fL in group 3,as well as (11.27 ±0.85)fL and (13.89 ± 1.76)fL in group 4,respectively,which were both significantly higher than those in group 1 [(10.41 ±0.63)fL and (11.93 ± 1.22)fL] as well as in group 2 [(10.38 ± 0.51) fL and (12.33 ± 1.28) fL] (all P ＜ 0.05).Both MPV and PDW levels of group 4 were higher than those of group 3,but there was no significant difference (P =0.254,0.388).As for males,MPV level was increased gradually in group 2 [(10.29 ±0.58)fL],group 3 [(10.67 ± 1.08)fL] and group 4 [(11.42 ±0.90) fL] (all P＜0.05),but there was no significant difference between group 1 [(10.27 ± 0.55)fL] and group 2.For females,MPV level was (11.37 ± 0.69) fL in group 3 and (11.13 ± 0.79) fL in group 4,both which were significantly higher than that in group 1 [(10.55 ± 0.70) fL] and group 2 [(10.42 ± 0.49) fL],respectively (all P ＜ 0.05),but there was no significant difference between group 3 and group 4 (P ＞ 0.05).Conclusion High MPV level may be an important risk factor for the development of DME in DR patients.Platelet parameter surveillance can aid in the monitoring of this disease.%目的 探讨2型糖尿病患者平均血小板体积(mean platelet volume,MPV)与糖尿病性黄斑水肿(diabetic macular edema,DME)的关系.方法 本研究共有四组患者,分别是健康对照组(组1,n=40例)、有糖尿病无糖尿病视网膜病变(diabetic retinopathy,DR)组(组2,n=40例)、有DR无DME组(组3,n=40例)和DR伴DME组(组4,n=40例),采集患者一般信息,散瞳眼底彩照和OCT检查,检测外周血血小板4参数:血小板计数(platelet count,PLT)、MPV、血小板平均分布宽度(platelet distribution width,PDW)和血小板压积(plateletcrit,PCT).比较4组患者PLT、MPV、PDW和PCT.结果 四组间MPV和PDW差异均有统计学意义(均为P＜0.05),而PLT和PCT差异均无统计学意义(均为P＞0.05).组间比较MPV和PDW显示,组3[(11.07±1.06)fL、(13.57±2.25)fL]和组4[(11.27±0.85) fL、(13.89±1.76)fL]分别均高于组1[(10.41±0.63)fL、(11.93±1.22) fL]和组2[(10.38±0.51)fL、(12.33±1.28)fL](均为P＜0.05).组4的MPV和PDW均高于组3,但差异均无统计学意义(P=0.254、0.388).男性患者MPV组间比较显示,组2(10.29±0.58)fL、组3(10.67±1.08)fL和组4(11.42±0.90)fL逐渐增大(P＜0.05),而组1(10.27±0.55)fL和组2间差异无统计学意义(P＞0.05).女性患者MPV组间比较显示,组3(11.37±0.69) fL和组4(11.13±0.79)fL分别均高于组1(10.55±0.70)fL和组2(10.42±0.49)fL(均为P＜0.05),组3和组4间差异无统计学意义(P＞0.05).结论 MPV升高可能是2型糖尿病DR患者发生DME的一个重要危险因素,监测血小板参数有助于DR病情监控.
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