角膜补偿眼压(IOPcc)和5种眼压校正公式所得校正眼压的一致性及IOPcc、模拟Goldmann眼压与眼球各参数的相关性分析

摘要

目的 比较眼反应分析仪测得的角膜补偿眼压(corneal-compensated intraocular pressure,IOPcc)和Sirius眼前节分析系统内置的5种眼压校正公式所得校正眼压的一致性,分析IOPcc、模拟Goldmann眼压(Goldmann-correlated intraocularpressure,IOPg)与眼球各参数的相关性.方法 选取2016年11月至2017年3月在我院眼科中心行近视激光治疗的患者90例90眼,年龄18～ 37(24.47±5.57)岁.应用Sirius眼前节分析系统对所有患者按常规方法测量3次,选择最佳测量结果作为各参数最终结果.应用眼反应分析仪测量患者的角膜生物力学参数.根据眼反应分析仪测量的IOPg输入Sirius眼前节分析系统内置的5种眼压校正公式进行计算,得到的校正眼压分别记录为Dresdner校正眼压、Ehlers校正眼压、Kohlhaas校正眼压、Orssengo/Pye校正眼压和Shah校正眼压.将所得的5种校正眼压和非接触性眼压计眼压与眼反应分析仪测得的IOPcc进行一致性分析.对IOPcc、IOPg与角膜滞后量、角膜阻力因子、眼球各参数进行相关分析.结果 Kohlhaas校正眼压和IOPcc比较差异有统计学意义(P＜0.05).Dresdner校正眼压、Orssengo/Pye校正眼压与IOPcc的一致性较好,95％一致性界限分别为(-2.09 ～2.55)mmHg、(-2.38 ～2.37)mmHg;其中Dresdner校正眼压与IOPcc的95％一致性界限宽度最窄.IOPcc与角膜滞后量、角膜阻力因子以及眼球各参数均无相关性,而IOPg与角膜阻力因子、中央角膜厚度、角膜体积呈正相关关系(均为P＜0.05).结论 Dresdner校正眼压、Orssengo/Pye校正眼压与IOPcc的一致性较好;眼球大部分参数对IOPcc影响小.%Objective To compare the agreement between corneal-compensated intraocular pressure (IOPcc) measured by ocular response analyzer (ORA) and 5 corrected intraocular pressures from Sirius anterior system,and analyze the correlation of ocular biometries with IOPcc and Goldmann-correlated IOP (IOPg).Methods Together 90 eyes of 90 patients,aged 18-37 (24.47 ± 5.57) years,without refractive surgery contraindications undergoing myopic laser treatment were enrolled in this study.Each eye was measured 3 times by Sirius anterior system,with the best results of IOPcc and IOPg was selected.And patients' corneal biomechanical parameters were measured using an ORA (Reichert,Inc.,USA).The IOPg from ORA were entered into the 5 IOP formulas embedded in Sirius anterior system to generate the corrected IOPs,which were recorded as the Dresdner corrected IOP,Ehlers corrected IOP,Kohlhaas corrected IOP,Orssengo/Pye corrected IOP and Shah corrected IOP,accordingly.Meanwhile the agreement of the 5 corrected IOPs and the IOP measured non-contact tonometer with IOPcc was analyzed,respectively.Corneal biomechanics,including corneal hysteresis and corneal resistance factor,and ocular biometries were also recorded,and the correlation of these parameters with IOPcc and IOPg was assessed with correlation coefficient.Resuits The pair comparison of IOPcc and Kohlhaas corrected IOP was statistically significant (P ＜ 0.05).Dresdner corrected IOP and Orssengo/Pye corrected IOP showed a good agreement with IOPcc,and the 95％ limits of agreements (LoA) were (-2.09 ～2.55)mmHg (1 kPa=7.5 mmHg) and (-2.38～2.37) mmHg,respectively.The 95％LoA of Dresdner's corrected IOP and IOPcc was the narrowest.No statistical significance was found between IOPcc and corneal hysteresis,corneal resistance factor,ocular biometries,but there was a positive correlation between IOPg and corneal resistance factor,central corneal thickness,and corneal volume (all P ＜ 0.05).Conclusion Dresdner and Orssengo/Pye corrected IOP had a good agreement with IOPcc,and most ocular biometries have a little effect on IOPcc.