轻微型肝性脑病患者后扣带回与双侧海马间功能连接静息态功能MRI研究

摘要

目的：探讨轻微型肝性脑病（MHE）患者静息态下后扣带回（PCC）与双侧海马间功能连接（FC）的改变情况。方法：采用静息态功能磁共振成像（rs-fMRI）技术，分析17例 MHE患者（MHE组）和17例健康对照者（HC组）静息态下脑功能活动，观察 MHE患者静息态下PCC与双侧海马间的功能连接情况，并与数字-符号试验（DST）和数字连接试验-A （NCT-A）评分进行相关分析。结果：与 HC组相比，MHE组 PCC 与右侧海马间 FC 减低（P＜0．05，K≥10体素）；MHE组PCC和右侧海马FC分数与DST评分呈显著正相关，与NCT-A评分呈显著负相关（P＜0．05，K≥体素）。结论：MHE患者脑功能存在损伤，海马与后扣带回间连接强度可以提示 MH E患者的认知功能状态。%Objective:To investigate the resting-state functional connectivity (FC)between bilateral hippocampus and posterior cingulate cortex (PCC)at functional MRI in patients with minimal hepatic encephalopathy (MHE).Methods:Se-venteen MHE patients and seventeen healthy controls (HC)underwent standard resting-state (rs)fMRI scan.The rsfMRI data were analyzed to observe the changes of the functional connectivity between bilateral hippocampus and PCC.The corre-lation analysis was performed between the results of digit symbol test (DST)and number connection test-A (NCT-A)and FC between the bilateral hippocampus and the PCC in MHE patients.Results:Compared with HC,MHE patients showed decreased FC between the PCC and the left hippocampus.In MHE patients,FC values between PCC and left hippocampus showed positive correlation with the DST scores,and negative correlation with the NCT-A scores.Conclusion:rs-MRI can show the damage in the brain functional in MHE patients,the intensity of functional connectivity between bilateral hippo-campus and posterior cingulate cortex can be indicators to evaluate the cognitive function of MHE patients.