家畜的 Toll 样受体（TLRs）是家畜天然免疫相关分子家族中的重要组成部分。不同家畜表达的 TLRs 分子也各不相同，而同一种家畜的不同组织中表达的 TLRs 分子也不一定相同。这些 TLRs 分子在家畜疫病的发生、发展及治疗中也具有重要作用。目前虽然对于人和小鼠 TLRs 分子的研究已经较为全面，但是对于家畜 TLRs 的研究并不十分深入。论文主要就不同家畜 TLRs 分子研究的概况、不同家畜的TLRs 在组织中的分布，以及 TLRs 在相关家畜疫病中的重要作用进行简要概述，以期对家畜 TLRs 分子信号转导通路的研究及家畜疫病的防控、新型疫苗和佐剂的开发提供参考。%Toll-like receptor (TLRs)in livestock is an important part of the natural immunity.TLR expression in different animals is also different,and TLRs expression in different kind of animal tissues is not necessarily the same.These TLRs play an important role in the occurrence,development and treatment of livestock diseases.Al-though the current study of TLRs in mice and human is very deep but the comprehensive study in livestock is not deep enough.This article provided an overview of the TLRs in different domestic animals and introduced the TLRs in the distribution of different species of animal tissues,as well as the effects in associated livestock diseases in prder to provide the references in the study of livestock TLRs molecule signal transduction pathway,animal disease pre-vention and control and the development of novel vaccines and adjuvants.
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