阴茎勃起及勃起功能障碍的研究进展

摘要

Recent advances in the research on erectile dysfunction (ED) has more clearly explained the mechanism of penile erection, which is a hemodynamic process involving relaxation of corpus caver nosum smooth muscle and related arterials, and NO-cGMP signaling pathway proven to play an impor tant role on modulating the relaxation of corpus cavernosum smooth muscle. Studies on NOS and PDEs not only provide strong evidence for the clinical treatment of ED, but also provide the chance to devel op Sildenafil. Although the gene therapy for ED is still in the laboratory stage by now, it may be one of the effective clinical therapies for ED in future.%勃起功能障碍的基础研究在近十年来取得了较大进展，一氧化氮-cGMP(NO-cGMP)通路的发现使得阴茎平滑肌松弛的机制进一步阐明。一氧化氮合酶(NOS)、磷酸二酯酶(PDEs)的研究为勃起功能障碍的临床治疗提供了坚实的基础，进而促使了万艾可的问世。目前，勃起功能障碍的基因治疗尚停留在实验室阶段，但随着分子生物学的深入研究，转基因疗法可能成为临床上治疗勃起功能障碍的有效方法之一。