In addition to tumor cells, tumors contain tumor cells, other stroma cells and the extracellular matrix. These are collectively called the "tumor microenvironment". The stroma cells include fibroblasts, endothelial cells, inflammatory cells, adipose cells and so on. Interestingly, the distribution of stroma cells, the properties of the extra cellular matrix (ECM) and the metabolites available can vary greatly between areas of a single tumor. The state of these stroma cells within tumors has a profound effect on metastasis and can even be used to predict the likelihood of recurrence. In this review, each of the components of this dynamic network will be examined. We will show that there are a multitude of complex interactions and a host of molecules involved in tumorogenesis and metastasis.%在肿瘤组织中,除了肿瘤细胞外还有其他成分包括间质细胞和细胞外基质(ECM),这些共同构成肿瘤微环境.这些间质细胞包括:成纤维细胞、内皮细胞、炎症细胞、脂肪细胞等.间质细胞的分布、细胞外基质的组成和代谢产物在同一肿瘤中明显不同.肿瘤细胞周围的间质细胞状态对肿瘤的转移产生重要影响,甚至可以用来预测肿瘤复发.肿瘤的发生发展包括众多成分之间的相互作用,本文论述了这一复杂网络的各个组成部分.
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