Objective: The aim of the present study was to investigate the effects of Oxcarbazepine (OXC) on high voltage active calcium currents in trigeminal ganglion neurons in rat model of migraine. Methods: Male adult Sprague Dawley rate were randomly divided into 3 groups (each group n=8): normal saline treatment group, IS infusion group, OXC prevention group. We report the effects of OXC on calcium currents, using a conventional whole-cell patch clamp technique fromacutely isolated rat trigeminal ganglion neurons. Results: OXC inhibited calcium currents. Moreover, OXC could shift the voltage-gated activation curve for calcium channel in the depolarizing direction; shift the steady-state inactivation curve for calcium channel in the hyperpolarizing direction. Conclusion: OXC, whose preventative action in migraine prophylaxis may involve blockade of Ca2+ entry across the cell membrane, prevent migraine efficiently. Considering its complex modulatory effects on voltage-gated calcium channels, OXC might have potential effects on the nervous system and lead to a change in excitability of nociceptive afferent fibers.%目的:研究奥卡西平(Oxcarbazepine,OXC)对大鼠三文神经节神经元钙电流的调控作用.方法:SD大鼠随机分为3组(n=8):生理盐水组(NS组),致炎剂组(IS组),OXC预防组.应用膜片钳技术,采用全细胞记录方式,观察OXC对偏头痛大鼠急性分离的三叉神经节的高电压激活钙电流(HVA-ICa)的调控作用.结果:OXC能够抑制钙电流,使钙电流的激活曲线向去极化方向移动,使钙电流的失活曲线向超级化方向移动.结论:OXC可能通过抑制钙离子进入细胞膜,来预防偏头痛的发作.同时OXC可能对外周神经系统及伤害感受的传入的兴奋性起到调控作用.
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