Objective: To investigate the effects of modafinil od working memory during 48h sleep deprivation (SD) and provide related information for its further military use. Methods: Eighteen healthy male volunteers underwent twice 48h sleep deprivation tests in a crossover design experiment. The sleep deprivation started at 7:00 of the 1st day and ended at 7:00 of the 3rd day. Modafinil or placebo was given at 0:00,12:00 of the 2nd day and at 0:00 of the 3rd day. Working memory tests were performed at 7:00 of the 1st day, 2:00, 14: 00 of the 2nd day and at 2:00, 7:00 of the 3rd day. Results: There was significant difference in the correct rate and in the reaction time between modafinil group and placebo group in working memory test (P<0.01). Compared with that of modafinil group, reaction time of placebo group was longer. And the correct rate of modafinil group was higher than that of the placebo group. The benefits of modafinil against SD become more obvious with the time of SD. Conclusions: Modafinil can alleviate the deterioration of working memory induced by sleep deprivation. Modafinil is a kind of effective countermeasure against the injury resulted from sleep deprivation.%目的:观察在睡眠剥夺条件下莫达非尼对工作记忆的改善作用,为此药在我军的应用策略提供实验依据.方法:18名健康男性志愿者,在两次睡眠剥夺实验中交叉服用莫迭非尼和安慰剂,睡眠剥夺时间从第一天的07:00到第3d的07:00,并于第二天的0:00、12:00和第三天的0:00分别服用莫达非尼100mg或安慰剂.采用随机双盲设计给药,并在第一天的07:00、第二天的02:00和14:00以及第三天的02:00和07:00安排工作记忆测验.结果:工作记忆测验中,两组的反应时和正确率均有统计学差异(P＜0.01),莫达非尼组的反应时要快于安慰剂组,正确率也要高于安慰剂组.莫达非尼对工作记忆的改善效果随着睡眠剥夺时间的延长而更趋明显.结论:莫达非尼对睡眠剥夺条件下个体的工作记忆有改善作用,是较为理想的睡眠剥夺对抗药物.
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