Effect of a novel histamine subtype-3 receptor inverse agonist and modafinil on EEG power spectra during sleep deprivation and recovery sleep in male volunteers

Lynette M. James; Robert Iannone; John Palcza; John J. Renger; Nicole Calder; Kristine Cerchio; Keith Gottesdiener; Richard Hargreaves; M. Gail Murphy; Julia Boyle; Derk-Jan Dijk

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Effect of a novel histamine subtype-3 receptor inverse agonist and modafinil on EEG power spectra during sleep deprivation and recovery sleep in male volunteers

机译：新型组胺亚型3受体逆激动剂和莫达非尼对男性志愿者睡眠剥夺和恢复性睡眠期间脑电功率谱的影响

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Histamine and dopamine contribute to the maintenance of wakefulness.

机译：组胺和多巴胺有助于保持清醒状态。

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来源
《Psychopharmacology》 |2011年第4期|p.643-653|共11页
作者
Lynette M. James; Robert Iannone; John Palcza; John J. Renger; Nicole Calder; Kristine Cerchio; Keith Gottesdiener; Richard Hargreaves; M. Gail Murphy; Julia Boyle; Derk-Jan Dijk;
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作者单位

Surrey Sleep Research Centre, Faculty of Health and Medical Sciences, University of Surrey, Egerton Road, Guildford, GU2 7XP, UK;

Merck &amp Co., Inc., Merck Research Laboratories, West Point, Pennsylvania, 351 North Sumneytown Pike, 19454, North Wales, PA, USA;

Merck &amp Co., Inc., Merck Research Laboratories, West Point, Pennsylvania, 351 North Sumneytown Pike, 19454, North Wales, PA, USA;

Merck &amp Co., Inc., Merck Research Laboratories, West Point, Pennsylvania, 351 North Sumneytown Pike, 19454, North Wales, PA, USA;

Merck &amp Co., Inc., Merck Research Laboratories, West Point, Pennsylvania, 351 North Sumneytown Pike, 19454, North Wales, PA, USA;

Merck &amp Co., Inc., Merck Research Laboratories, West Point, Pennsylvania, 351 North Sumneytown Pike, 19454, North Wales, PA, USA;

Merck &amp Co., Inc., Merck Research Laboratories, West Point, Pennsylvania, 351 North Su;

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正文语种 eng
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关键词
H3; EEG; Alerting effects; Excessive daytime sleepiness;

机译：H3;EEG;缓解作用;白天嗜睡;

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专利

1. Effect of a novel histamine subtype-3 receptor inverse agonist and modafinil on EEG power spectra during sleep deprivation and recovery sleep in male volunteers. [J] . James LM, Iannone R, Palcza J, Psychopharmacology . 2011,第4期

机译：新型组胺亚型3受体反向激动剂和莫达非尼对男性志愿者睡眠剥夺和恢复睡眠期间脑电功率谱的影响。
2. Acute alertness-promoting effects of a novel histamine subtype-3 receptor inverse agonist in healthy sleep-deprived male volunteers. [J] . Iannone R, Palcza J, Renger JJ, Clinical Pharmacology and Therapeutics . 2010,第6期

机译：新型组胺亚型3受体逆激动剂对健康睡眠不足的男性志愿者的急性警觉性促进作用。
3. Comparison of the effects of modafinil and sleep deprivation on sleep and cortical EEG spectra in mice. [J] . Kopp C, Petit J, Magistretti P, Neuropharmacology . 2002,第1期

机译：比较莫达非尼和睡眠剥夺对小鼠睡眠和皮质EEG谱的影响。
4. Power Spectral Analysis of Recovery Sleep of Sleep Deprivation and Hypnotic Drug Induced Sleep [C] . Zhouyan Feng, Fei Gu . 2005

机译：睡眠剥夺和催眠药诱导的睡眠恢复睡眠的功率谱分析
5. Heat shock protein expression in sleep deprivation and recovery sleep [D] . Rishipathak, Deepali 2003

机译：睡眠剥夺和恢复性睡眠中热休克蛋白的表达
6. Differential Effects of a Dual Orexin Receptor Antagonist (SB-649868) and Zolpidem on Sleep Initiation and Consolidation SWS REM Sleep and EEG Power Spectra in a Model of Situational Insomnia [O] . Paolo Bettica, Lisa Squassante, John A Groeger, 2012

机译：在情况失眠模型中双重Orexin受体拮抗剂（SB-649868）和唑吡坦对睡眠启动和合并SWSREM睡眠和EEG功率谱的差异作用
7. Effect of a novel histamine subtype-3 receptor inverse agonist and modafinil on EEG power spectra during sleep deprivation and recovery sleep in male volunteers. [O] . James, LM, Iannone, R, Palcza, J, 2011

机译：新型组胺亚型3受体反向激动剂和莫达非尼对男性志愿者睡眠剥夺和恢复睡眠期间脑电功率谱的影响。

Effect of a novel histamine subtype-3 receptor inverse agonist and modafinil on EEG power spectra during sleep deprivation and recovery sleep in male volunteers

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