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USE OF SOMATOSTATIN RECEPTOR AGONISTS IN THE TREATMENT OF HUMAN DISORDERS OF SLEEP HYPOXIA AND OXYGEN DEPRIVATION
USE OF SOMATOSTATIN RECEPTOR AGONISTS IN THE TREATMENT OF HUMAN DISORDERS OF SLEEP HYPOXIA AND OXYGEN DEPRIVATION
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机译:生长抑素受体激动剂在治疗人类睡眠不足低氧症和氧剥夺症中的应用
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摘要
The invention relates to a method of treating diverse human disorders that may arise, in part, out of sleep hypoxia and oxygen deprivation occurring in the context of sleep apnea/hypopnea disturbances. The disorders that may be treated by the invention comprise gastroesophageal reflux disease (GERD), asthma-associated gastroesophageal reflux (GER), GER-associated asthma, asthma, cardiomyopathy, cardioarrhythmia, congestive heart failure, sudden infant death syndrome, and diverse neurologic conditions. The mode of treatment uses somatostatin receptor ligands (SstRLs), particularly somatostatin-receptor agonists. The invention concerns the method of treatment utilizing, and compositions comprising SstRLs and somatostatin receptor agonists, including agonists of the somatostatin receptor types 2 and 5, particularly, the type 2A receptor (SsR-2A), including octreotide and lanreotide.
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