中国北方地区血清钙、维生素D水平与乳腺癌的相关性研究

摘要

目的:探讨中国北方地区血清钙、维生素D水平与乳腺癌及相关临床因素的关系.方法:选取2007年12月至2012年7月哈尔滨医科大学附属肿瘤医院794例女性乳腺癌患者及976例乳腺良性肿瘤患者,并以128例健康妇女为对照,取空腹血清采用原子吸收分光光度法检测三组血清钙含量,采用放免法检测三组中162例血清25(OH)D含量,结合相关临床资料进行分析.结果:乳腺癌组血清钙含量为2.26± 0.12 mmol/L,乳腺良性肿瘤组血清钙含量为2.26±0.09 mmol/L,正常对照组血清钙含量为2.25±0.24 mmol/L,经方差分析,三组总体均数差别无统计学意义(P＞0.05);乳腺癌患者的血清钙水平与年龄、TNM分期、BMI、绝经情况、乳腺癌家族遗传史无关(P＞0.05).乳腺癌组血清25(OH)D含量为41.91±7.55 ng/mL,乳腺良性肿瘤血清25(OH)D含量为54.62±7.48 ng/mL,正常对照组血清25(OH)D含量为56.15±8.87 ng/mL,经方差分析,乳腺癌患者血清25(OH)D含量低于乳腺良性肿瘤组,差别有统计学意义(P＜0.05),乳腺良性肿瘤组与正常对照组差别无统计学意义(P＞0.05);乳腺癌患者的维生素D水平与年龄、TNM分期、BMI、绝经情况有关(P＜0.05),而与乳腺癌家族遗传史无关(P＞0.05).结论:中国北方地区的乳腺癌患者血清钙水平与乳腺良性肿瘤患者无明显差异.乳腺癌患者的维生素D水平低于乳腺良性肿瘤患者,并且与年龄、TNM分期、BMI、绝经情况有关.维生素D水平降低可能与乳腺癌的发生有关,高水平的维生素D可能会降低女性患乳癌的风险.%Objoctive:To study the levels of serum calcium and vitamin D of breast cancer in North China,and to make a further study about the relationships between them and related clinical factors of breast cancer.Methods:We selected 794 cases of female breast cancer,976 cases of benign breast tumor,and 128 eases of physical-health women as normal control group,who were all from the Tumor Hospital of Harbin Medical University from 2007 to 2012.We took fasting-serums.Serum calcium levels were detected by atomic absorption spectrophotometry.Serum 25(OH)D levels were detected by radioimmunoassay.Then we combined with related clinical data to analyze the results.Results:Serum calcium content of breast cancer patients was 2.26± 0.12 mmol/1,that of benign breast tumor patients was 2.26 ± 0.09 mmol/1,that of normal control group was 2.25 ± 0.24 mmol/l,and the differences were not statistically significant (P＞0.05); The serum calcium level of breast cancer patients was not related to age,TNM stage,BMI,menopausal conditions and family history of breast cancer (P＞0.05).Serum 25 (OH)D content of breast cancer was 41.91 ± 7.55 ng/ml,that of benign breast tumor was 54.62± 7.48 ng/ml,that of normal control group was 56.15± 8.87 ng/ml.The content of breast cancer was lower than that of benign breast tumor and the difference was statistically significant (P＜0.05),but there was no statistical difference between benign breast tumor and normal control group (P＞0.05).The serum 25(OH)D level of breast cancer patients was correlated with age,TNM stage,BMI,menopausal conditions (P＜0.05),but not related to family history of breast cancer (P＞0.05).Conclusion:There was no significant difference in serum calcium level between breast cancer patients and benign breast tumor ones in North China.Vitamin D levels of breast cancer patients was lower than that of benign breast tumor patients; Vitamin D levels of breast cancer patients was correlated with age,TNM stage,BMI,menopause conditions.The deficiency of vitamin D may be one of the risk factors of breast cancer,and high level of vitamin D may reduce the risk of breast cancer.