炎症性肠病患者的肠道菌群分布与血清TNF-α与IL-6水平的相关性

摘要

目的:探讨炎症性肠病患者的肠道菌群分布与血清肿瘤坏死因子-α(TNF-α)与白介素-6(IL-6)水平的相关性.方法:选择我院收治的172例炎症性肠病患者作为观察组,同期选择在我院经询问病史及体格检查无消化道疾病的172例患者作为对照组,检测两组肠道菌群的分布与血清TNF-α与IL-6水平,并分析炎症性肠病患者肠道菌群分布与血清TNF-α与IL-6水平的相关性.结果:观察组的肠球菌、粪肠球菌和大肠埃希杆菌含量明显高于对照组,而双歧杆菌含量明显低于对照组(P＜0.05).观察组的血清TNF-α与IL-6值分别为0.98± 0.54 ng/mL和0.98± 0.38 pg/mL,都明显高于对照组的0.61± 0.37 ng/mL和0.55± 0.34 pg/mL(P＜0.05).观察组的双歧杆菌含量与TNF-α与IL-6呈现明显负相关性(P＜0.05),而肠球菌、粪肠球菌、大肠埃希杆菌含量与TNF-α与IL-6都呈现明显正相关性(P＜0.05).结论:炎症性肠病患者存在益生菌含量减少、有害菌含量增加的现象,这可能与患者血清促炎因子过量表达有关,二者的共同作用可促进炎症性肠病的发生及进展.%Objective:To investigate the correlation of intestinal flora distribution with the serum levels of TNF-α and IL-6 in the inflammatory bowel disease.Methods:172 patients with inflammatory bowel disease in our hospital were selected as the observation group,and 172 patients without digestive tract disease history and positive physical examination results were selected as the control group.The intestinal flora distribution and serum levels of TNF-α and IL-6 were detected and the correlation of them were analyzed.Results:The contents of Enterococcus,Fecal streptococcus,Escherichia coli in the observation group were significantly higher than those in the control group,while the Bacillus content of control group was significantly lower than that of the control group (P＜0.05).The serum levels of TNF-α and IL-6 in the observation group were 0.98± 0.54 pg/mL and 0.98± 0.38 ng/mL respectively,which were significantly higher than those in the control group (0.61 ± 0.37 ng/mL and 0.55 ± 0.34 pg/mL) (P＜0.05).The Bacillus showed significantly negative correlation with the serum TNF-α and IL-6 levels in the observation group (P＜0.05),and the Enterococcus,Fecal streptococcus,Escherichia coli showed significantly positive correlation with the serum TNF-α and IL-6 levels(P＜0.05).Conclusion:The increase of Enterococcus,Fecal streptococcus,Escherichia coli and decrease of Bacillus were observed in the patients with inflammatory bowel disease,which could be related to the over-expression of serum TNF-α and IL-6.Both changes could promote the occurrence and development of inflammatory bowel disease.