鼻炎患者血清中IL-27、IL-17、IL-10在变应性的表达及临床意义

摘要

Objective:To study the expression and clinical significance of interleukin-27 (IL-27),interleukin-17 (IL-17),interleukin-10 (IL-10)in serum of patients with allergic rhinitis.Methods:A total of 60 patients with allergic rhinitis,who were admitted to Fuzhou General Hospital of PLA from May 2013 to May 2014,were chosen as study group;in addition,60 healthy volunteers were chosen as control group.The expression of IL-27,IL-17 and IL-1 0 in the serum of the selected subjects were detected by enzyme-linked immunosorbent assay (ELISA),and the correlation among them was analyzed.Results:The serum levels of IL-27 and IL-10 in the study group were significantly lower than those in the control group,and the difference was statistically significant (P＜0.05),and the level of IL-17 in the study group was significantly higher than that in the control group,the difference was statistically significant(P＜0.05).There was a negative correlation between serum IL-27 and IL-17 (r=-0.372,P=0.035) in the study group,while there was a positive correlation between IL-27 and IL-10 (r=0.524,P=0.026),and there was no correlation between IL-17 and IL-10 (r=0.519,P=0.318).Conclusion:The levels of IL-27 and IL-10 in the patients with allergic rhinitis are lowly expressed,but the level of IL-17 is highly expressed.IL-27 may have immunomodulatory effects on IL-17 and IL-10.%目的:探讨鼻炎患者血清中白细胞介素-27(IL-27)、白细胞介素-17(IL-17)、白细胞介素-10(IL-10)在变应性中的表达以及临床意义.方法:选取2013年5月到2014年5月我院收治的变应性鼻炎患者60例为研究组,另外选取健康志愿者60例为对照组,应用酶联免疫吸附试验(ELISA)检测入选者血清中的IL-27、IL-17以及IL-10的表达情况,并分析其相关关系.结果:研究组血清中IL-27、IL-10水平显著低于对照组,差异具有统计学意义(P＜0.05);研究组IL-17水平显著高于对照组,差异具有统计学意义(P＜0.05);研究组患者血清中的IL-27和IL-17呈负相关关系(r=-0.372,P=0.035),IL-27和IL-10呈正相关关系(r=0.524,P=0.026),而IL-17和IL-10无相关关系(r=0.519,P=0.318).结论:变应性鼻炎患者中IL-27和IL-10呈低表达,而Ⅱ-17呈高表达,IL-27可能对IL-17和IL-10具有免疫调节的作用.