Objective To estimate the effectiveness of seasonal influenza vaccine during 2010 to 2012 seasons. Metho-ds The 1 ∶ 2 matched case-control study was conducted among children aged 6-59 months. The influenza cases from surveil-lance sites in Guangzhou were laboratorial confirmed during the study periods. The healthy controls were randomly selected from children aged 6 to 59 months in the Children’ s Expanded Programmed Immunization Administrative Computerized Sys-tem. Vaccine effectiveness was analyzed by conditional logistic regression. Results The vaccination information for 1 255 sets of subjects were analyzed in 2 influenza seasons in Guangzhou, China. Protective rate for vaccination during the 2010-2011 and 2011-2012 seasons for children 6-59 months were 73. 2% (95% confidence interval (CI):52. 2-85. 0) and 52. 9% (95%CI:42. 1-61. 7), respectively. Full vaccination provided more protective effect than partial vaccination. The VE decreased from 68. 9% (95% CI:57. 5-77. 2) in 1-3 months after vaccination to 48. 4% (95% CI:33. 8-59. 7) in 4-6 months after vaccination. Conclusions This post-licensing study of VE found that moderate protection against influenza for vaccinated children aged 6 to 59 months. Annual, full and timely vaccination should be encouraged for children.%目的：评价2010-2012年度季节性流行性感冒疫苗(流感疫苗)对儿童的上市后保护效果。方法选择2010-2012年度6~59月龄的实验室诊断流感病例为病例组,在儿童预防接种信息系统中随机选择健康儿童为对照组,进行1∶2匹配的病例对照研究,采用条件Logistic回归计算保护效果。结果研究中共纳入1255组研究对象。2010-2011和2011-2012年度,流感疫苗对6~59月龄儿童完全免疫的保护效果分别为73.2%(95%可信限(CI)：52.2~85.0)和52.9%(95%CI：42.1~61.7),对6~35月龄儿童的保护效果优于36~59月龄儿童,完全免疫的保护效果优于部分免疫。流感疫苗的保护效果从1~3月的68.9%(95%CI：57.5~77.2)衰减至4~6月的48.4%(95% CI,33.8~59.7)。结论流感疫苗对6~59月龄儿童具有一定的保护效果,儿童接种疫苗后可以减少52.9%~73.2%的流感病例,建议儿童每年及时进行全程免疫。
展开▼
