小儿急性上呼吸道感染抗生素使用临床随机对照观察

摘要

目的：比较单一抗生素与二联抗生素在治疗小儿急性细菌性上呼吸道感染的疗效、疗程及疾病转归等方面的差别。方法：将80例急性上呼吸道感染住院患儿随机分为两组，每组40例，治疗组使用氯唑西林钠，对照组使用青霉素钠联合头孢哌酮舒巴坦钠，两组均使用炎琥宁，进行对照观察。结果：治疗组有效率77.5%，对照组82.5%，经统计学分析，差异无统计学意义（P >0.05）。两组疗程、疾病转归及不良反应比较，差异无统计学意义。结论：使用一种抗生素治疗急性细菌性上呼吸道感染可以达到预期目的，联合静脉使用抗生素并不能加速症状、体征改善，不能显著提高有效率和改善预后，也不能缩短疗程。临床上应避免仅凭个人经验无依据多重应用抗生素。%Objective:Compared the differences in clinical efficacy,disease course and disease outcome between single and joint use of antibiotics in treatment of children with acute bacterial upper respiratory infection. Methods:Eighty cases of hospitalized children with acute bacterial upper respiratory infection were divided randomly into two groups,40 cases of treat-ment group were treated with intravenous cloxacillin sodium,40 cases of control group were treated with intravenous penicillin sodium and cefoperazone and sulbactam sodium,all cases were treated with potassium sodium dehydroandroan drographolide succinate for injection,a parallel comparison observation was carried out between two groups. Results:After therapy,there were no significant differences in effective rates beween reatment group(77. 5% )and control group(82. 5% )(P > 0. 05). Both groups were also similar in disease course,disease outcome and adverse reactions. Conclusion:Use of single antibiotic treatment of acute bacterial upper respiratory infections can achieve the intended objective,joint use of antibiotics can not accelerate to improve the symptoms and signs,can not increase the significant effective rates,can not improve the disease outcome,nor short-ened course. Multiple use of antibiotics should be avoided only by personal experiences without clinical evidence.