Objective:Toinvestigatetheclinicaleffectandadverseofrecombinanthumantumornecrosisfactor(rmhTNF) for malignant pleural/peritoneal effusion. Methods:Fifty-six patients with malignant pleural/peritoneal effusion were enrolled and randomly divided into two groups. Group TNF was infused with rmhTNF,the another one was infused with cisplatin ( DDP). The effective rate,quality of life and adverse reaction were observed. Results:The total effective rate of TNF group was 89. 3%,while it was 64. 3% in DDP group. There was a significant difference between two groups(P<0. 05). The improve-ment rate of KPS in group TNF was 85. 7%,while it was 56. 7% in DDP group. There was a significant difference between two groups(P<0. 05). The adverse reaction rate of TNF group was significantly smaller than DDP group. Conclusion:The rmhTNF is more effective and response quickly with less adverse reaction for treatment of malignant pleural/peritoneal effusion.%目的:探讨重组改构人肿瘤坏死因子( rmhTNF)对恶性胸/腹腔积液的治疗作用。方法:观察56例恶性胸/腹腔积液的患者,随机分为TNF组(用rmhTNF胸/腹腔内注入治疗)和DDP组(用顺铂胸/腹腔内注入治疗),观察两组疗效、生存质量变化及不良反应情况。结果:TNF组总有效率明显高于DDP组(P<0.05);TNF组生存质量改善率明显高于DDP组(P<0.05);TNF组的不良反应发生率明显低于DDP组。结论:rmhTNF具有显著的消除胸/腹腔积液的作用,疗效明显优于DDP。
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