华蟾素注射液联合顺铂治疗非小细胞肺癌患者的临床疗效及对免疫功能的影响

摘要

目的：探讨华蟾素注射液联合顺铂对晚期非小细胞肺癌（ NSCLC）的疗效及对免疫功能的影响。方法：将60例晚期 NSCLC 患者随机分为两组，观察组30例，给予华蟾素注射液静脉滴注，每日1次，顺铂20 mg/ m2，14 d 为1疗程；对照组30例，给予紫杉醇60 mg/ m2联合顺铂20 mg/ m2治疗。观察两组患者用药后临床疗效及并发症情况，并观察两组患者免疫功能的变化。结果：治疗组临床疗效优于对照组，两组比较差异有统计学意义（ P ＜0.05）。与对照组比较，治疗组患者 CD3＋，CD4＋分布及 CD4＋/ CD8＋比值均高于对照组，两组比较差异有统计学意义（P ＜0.05）。结论：华蟾素注射液联合顺铂治疗非小细胞肺癌疗效显著，并发症少。%Objective:To explore the clinical effects and influence on the immune function of cinobufacini injection com-bined with cis - platinum in the treatment of patients with non - small cell lung cancer(NSCLC). Methods:Sixty patients with advanced NSCLC were randomly divided into two groups,30 cases of the observation group,were given cinobufacini injection of static drops,1 times one day,cisplatin(20 mg/ m2 ),14 days as a course of treatment;30 cases of control group were given pa-clitaxel(60 mg/ m2 )combined therapy with cisplatin(20 mg/ m2 ). To observe clinical curative effect and complications after the medication,and the changes of immune function in both groups. Results:The clinical curative effect of observation group was better than that of control group,difference of the two groups was statistically significant(P < 0. 05). Compared with control group,CD3 + ,CD4 + and CD4 + / CD8 + ratio of the treatment group patients were also higher than the control group,difference of the two groups was statistically significant(P < 0. 05). Conclusion:Cinobufacini injection combined with cis - platinum in the treatment of non - small cell lung cancer,curative effect was distinct,had fewer complications.