Effect of Pemetrexed combined with cis-platinum chemotherapy on matrix metalloproteinase VEGF, NK cells and immune function in patients with non-squamous non-small cell lung cancer

摘要

Objective: To explore effect of Pemetrexed combined with cis-platinum chemotherapy onmatrix metalloproteinase (MMPs), vascular esandothelial growth factor (VEGF), NK cells andimmune function in patients with non-squamous non-small cell lung cancer. Method: A totalof 86 cases of non-squamous non-small cell lung cancer patients were divided into controlgroup (n=44) and observation group (n=42), control group was given docetaxel combined cisplatinumchemotherapy, pemetrexed combined cis-platinum chemotherapy, was applied forobservation group. Compared MMP-2, MMP-9, VEGF, NK cells and immune function levelbefore and after treatment in both groups. Results: MMP-2, MMP-9, VEGF, NK cells, CD3+,CD4+, CD8+, CD4+/CD8+ level in both groups before treatment was no significant difference.After treatment, MMP-2, MMP-9, VEGF, CD8+level in both groups was significant lowerthan before treatment intra-group, and observation was lower than control group, there wassignificant difference. After treatment, NK cells, CD3+, CD4+, CD8+, CD4+/CD8+ level in bothgroups was increased dramatically than before treatment of intra-group, moreover, NK cells,CD3+, CD4+, CD8+, CD4+/CD8+level in observation group after treatment was obvious higherthan in control group after treatment, there was significant difference. Conclusion: Pemetrexedcombined with cis-platinum chemotherapy for non-squamous non-small cell lung cancer couldeffectively decrease serum MMPs, VEGF level and increase NK cell level, regulate immunefunction, with definite clinical significance.