Objective To observe the effect of clopidogrel combined with atorvastatin calcium in the preven-tion of cerebral infarction after transient ischemic attack ( TIA) . Methods 60 patients with TIA were randomly divid-ed into two groups. Patients in control group (n=30) were given clopidogrel 50 mg once daily after onset. Patients in observation group (n=30) were added atorvastatin calcium 20 mg once daily. All the patients were followed up for one year,The four indexes of blood lipid was detected using automatic biochemical analyzer before treatment and at the end of the follow-up,and the prothrombin time (PT),activated partial thromboplastin original time (APTT) and the PLT ( platelet) count were recorded. The carotid artery plaque of all the patients was examined by color Doppler ultra-sonography,and the quantity and quality of plaque was observed. The incidence of cerebral infarction,cerebral hemor-rhage and other adverse events were recorded during the follow-up period. Results After treatment,TC,TG,LDL-C of the observation group decreased (P0. 05 ) . The incidence of carotid plaque and the mean average keyed block plaque of observation group were significantly lower than those of control group (P0. 05). There were 1 case (3. 33%) and 6 cases (20. 00%) of cerebral infarction or cerebral hemorrhage in observa-tion group and control group,there were significant differences between the two groups (P0．05)。治疗后,观察组患者颈动脉平均斑块发生率及平均低回声斑块发生率均明显低于对照组(P0．05)。观察组在随访1年期间仅1例(3．33%)发生脑梗死或脑出血,对照组6例(20．00%)发生脑梗死或脑出血,两组患者随访期间脑血管不良事件发生率比较差异有统计学意义(P<0．05)。两组患者治疗期间均无皮肤粘膜、内脏等部位出血。结论氯吡格雷联合阿托伐他汀钙应用于TIA患者,通过调节血脂及抗血小板治疗,可明显降低脑梗死的发生率,效果明显优于单用氯吡格雷组。
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