NF-κB信号介导的慢性炎症与癌症形成的关系

摘要

潜在的炎症或炎症形成中微环境的恶性发展致使NF-κB通路激活,激活的NF-κB能够促进细胞因子(IL-6、IL-8、IL-12、IL-17、IL-22、TNF-α、iNOS、COX-2)表达,进而引发结肠癌、前列腺癌、肝癌、淋巴癌等肿瘤形成,表明NF-κB通路在炎症和癌症之间起到了重要的桥梁作用.为明确NF-κB通路在炎症和癌症之间的关系,笔者对相关文献进行综述.%Potential inflammation or malignant development of the microenvironment in the formation of in-flammation causes the activation of NF-κB pathway,thus promoting the expression of cytokines ( included IL-6,IL-8, IL-12,IL-17,IL-22,TNF-α,iNOS and COX-2) and causing the formation of tumors,such as,colon cancer,prostate cancer,liver cancer and lymphoid cancer. It shows that NF-κB pathway plays an important role in the process from in-flammation to cancer. The related articles about the relation of NF-κB pathway with the process of inflammation to cancer were reviewed to make clear the relationship.