含枳术宽中胶囊的四联疗法治疗单纯幽门螺杆菌感染性胃炎的临床回顾性研究

摘要

Objective To evaluate the effect of Zhizhukuanzhong capsule-containing quadruple therapy on chronic gastritis with Helicobacter pylori (Hp) infection. Methods Patients in treatment group (n=65) were treated with quadruple therapy ( Zhizhukuanzhong capsule+amoxicillin+pantoprazole+colloidal bismuth pectin) ,and patients in control group (n=59) were treated with quadruple therapy (maleic acid trimebutine maleate capsule+amoxicillin+pantoprazole+colloidal bismuth pectin) ,the treatment lasting for 2 weeks. The Hp eradication rate and recurrence rate after 6 months were evaluated. Results There was no significant difference in the total effective rate between treatment group and control group (89. 23% vs. 86. 44%,P>0. 05),while the recurrence rate in treatment group was lower than that of control group ( 12. 5% vs. 30. 56%, P0.05);半年后复发率分别为12.5%和30.56%,两组比较差异有统计学意义(P<0.05).结论含枳术宽中胶囊的四联疗法治疗单纯幽门螺杆菌感染性胃炎具有良好的疗效,可有效降低Hp根除率,并减少复发.