CRT+ARC技术在局部晚期肺癌患者中临床应用的初步研究

摘要

目的 研究CRT+ARC技术在局部晚期肺癌中临床应用情况.方法 选择2016年3月1日—2017年3月1日在我院放疗科放疗的100例局部晚期肺癌患者,随机分为实验组和对照组,每组各50例患者,实验组制定CRT+ARC计划,对照组制定三维适形放射治疗技术+调强放射治疗技术( Intensity-modulated radiotherapy,IMRT) ( CRT+IMRT)计划.根据世界卫生组织(World health organization,WHO)标准评估患者的近期疗效,根据影像学检查及放射治疗肿瘤学组( Ra-diaton therapy ognization group,RTOG)标准明确放疗主要副反应放射性肺炎发生情况.结果 实验组治疗有效率为82% ,对照组治疗有效率为76% ,两组差异无统计学意义(χ2 =0. 542,P=0. 461).实验组肺炎发生率为22% ,对照组肺炎发生率18% ,两组差异无统计学意义(χ2 =0. 250,P=0. 617).结论 CRT+ARC技术在局部晚期肺癌临床应用中,与CRT+IMRT相比,近期疗效和主要的副反应放射性肺炎都没有统计学差异.%Objective This paper investigated the clinical application of CRT+ARC technique in locally advanced lung cancer. Methods A total of 100 patients with locally advanced lung cancer who underwent radiotherapy in our hospital from March 1,2016 to March 1,2017 were randomly assigned to the experimental and control groups. Each group consisted of 50 patients. The CRT+ARC plans were made for the experimental group,and the CRT + intensity-modulated radiotherapy(IMRT)(CRT+IMRT) plans for the control group. According to the World Health Organization( WHO) criteria,the short-term efficacy of patients was as-sessed. According to the imaging examination and the Radiation Therapy Organization Group(RTOG)standard,the occurrence of major side effects of radiation pneumonia was identified. Results The effective rate of treatment was 82% in the experimental group and 76% in the control group. There was no difference in the effective rate between the two groups(χ2 =0. 542,P=0. 461). The incidence of pneumonia in the experimental group was 22% ,and 18% in the control group. There was also no difference in the incidence of pneumonia between the two groups(χ2 =0. 250,P=0. 617). Conclusion In the clinical application of locally advanced lung cancer, CRT+ARC technique has no difference in the short-term efficacy and the main side effects of radiation pneumonitis compared with CRT+IMRT.