细胞周期蛋白依赖性激酶抑制因子3在肿瘤中的研究进展

摘要

Cyclin-dependent kinase inhibitor 3(CDKN3)is a dual specificity phosphatase belonging to the CDC14s family. It has important clinical significance for early diagnosis,treatment and prognosis of tumors. The mechanism of CDKN3 in tumorigenesis and development has not yet been determined. Through reviewing the current research results,this paper summarizes the research pro-gress of CDKN3 in tumors from four aspects:cell cycle regulation,apoptosis and migration&invasion,CDKN3 mutant and its subcel-lular localization. The direction provides a reference to promote the clinical transformation of CDKN3 and improve the clinical diagno-sis and treatment of tumors.%细胞周期蛋白依赖性激酶抑制因子3(CDKN3)属于CDC14s家族的一种双特异性磷酸酶,对肿瘤的早诊、治疗及预后判断有重要的临床意义,但其在肿瘤发生发展中的作用机制目前尚未确定.本文通过对目前研究结果的回顾,从细胞周期调控、细胞凋亡及侵袭迁移、CDKN3突变体及其亚细胞定位四个方面对CDKN3在肿瘤中作用机制的研究进展进行概述,为明确下一步研究方向提供参考,从而促进CDKN3临床转化应用,提高肿瘤的临床诊治水平.