乙肝病毒感染性肝癌经TACE后Caspase-3与FAK的表达及意义

摘要

目的 探讨乙肝病毒感染性肝癌经TACE后Caspase-3与FAK的表达及意义. 方法 收集我院行TACE治疗后外科手术切除的肝癌组织标本38份,其中HBV感染者27份,无HBV感染者11份,采用免疫组化SP法检测残癌组织中Caspase-3与FAK的表达情况. 结果 HBV感染组中Caspase-3与FAK的阳性表达率分别为22.2%和81.5%,未感染组中阳性率分别为63.6%和36.4%,差异有统计学意义(P=0.024;P=0.017).HBV感染组中Caspase-3与FAK存在显著负相关关系(r=-0.433,P=0.020). 结论 HBV 感染性肝癌较非HBV感染性肝癌Caspase-3表达下调,FAK表达上调,乙肝病毒影响TACE的治疗疗效.%Objective To investigate the expression and significance of Caspase - 3 and FAK in hepatocarcinoma infected with Hepatitis B Virus after TACE. Methods To collect thirty - eight surgical specimens of hepatocarcinoma after TACE,including twenty - seven cases infected with HBV and eleven cases with no HBV.The Caspase - 3 and FAK in residual tissues of hepatocarcinoma were detected by using immunohistochemical SP method. Results The positive rate of Caspase - 3 and FAK in HBV group were respectively 22.2％ and 81.5％, and that of no HBV group were 63.6％ and 36.4％ respectively. The difference between the two groups was statistically significant( P = 0.024 ;P = 0.017 ). The expression of Caspase - 3 and FAK in HBV group was negatively correlated( r = -0.433 ,P =0.020 ). Conclusion HBV could suppress the expression of Caspase - 3 and up - regulate the expression of FAK. HBV effect the therapeutic effect of TACE.