髓源性抑制细胞——肿瘤免疫治疗的新靶点

摘要

Myeloid - derived suppressor eells(MDSCs)are a heterogeneous population of myeloid derived cells Which were amplified in pathological status,which is characterized as negatively regulating the anti -tumor immune response with the result of promoting tnmorigenesis and cancer development. It is a promising strategy to enhance the effect of cancer immimothcrapy through blocking the immimosupprcssivc pathway of MDSCs.%髓源性抑制细胞(Myeloid-derived suppressor cells,MDSCs)是在病理情况下扩增的一种髓源性抑制细胞群,其特点是能负向调节机体的抗肿瘤免疫反应从而促进肿瘤的发生和发展.通过阻断MDSCs的免疫抑制通路来提高肿瘤免疫治疗的效果,是一个颇有前景的治疗策略.