沈阳市子宫颈癌发病危险因素的病例对照研究

摘要

目的通过沈阳市子宫颈癌患者与沈阳市地区居民的病例对照研究,探讨子宫颈癌发病的危险因素.方法 以在辽宁省肿瘤医院住院的沈阳市子宫颈癌患者100例为病例,以沈阳市大东区二台子街道随机抽取的1000名子宫颈癌及癌前病变筛查的城市居民中非癌对象为对照,进行流行病学调查,采集HPV标本及宫颈脱落上皮液基细胞学检测标本,对获得的数据采用SPSS 13.0统计软件进行单因素卡方分析、logistic回归分析以及多因素logistic回归分析.结果 HPV感染(OR=221.62,95%CI:28.53~1721.51)、初次性生活年龄小于21岁(OR=6.65,95%CI:1.88~23.51)是子宫颈癌发病的危险因素,使用避孕套(OR=0.05,95%CI:0.01~0.18)是避免患宫颈癌的保护性因素.结论 清除HPV感染、倡导使用避孕套、树立科学的性生活观念、避免过早性体验,对降低沈阳地区子宫颈癌的发病具有重要意义.%Objective To evaluate the risk factors related to the incidence of cervical cancer through a case - control study on the the comparison of cervical cancer patients in Shenyang with local residents in Sheny-ang. Methods In reference to the patients with cervical cancer hospitalized in Liaoning Tumor Hospital from Shenyang,1 000 residents living in Ertaizi Street, Dadong District, Shenyang were randomly selected for the screening of cervical cancer and its precancerous lesions,the epidemiological investigations and the collections of HPV samples and cervical smear samples. The obtained data put into SPSS 13. 0 statistical software to make the a-nalysis of single -factor χ2 analysis, logistic regression analysis and multi -factor logistic regression analysis. Results HPV positive( OR =221. 62 ,95% CI:28. 53 ～ 1721.51 ),the first sex life younger than 21 years old( OR = 6. 65 ,95% CI: 1.88 -23.51 )is the risk factors of Cervical cancer;condom( OR =0. 05 ,95% CI:0. 01 ～0. 18 ) is the protect factor of Cervical cancer. Conclusion It is of great significance to remove HPV infection, advocate the use of condoms,establish a scientific concept of sexual life and avoid early sexual experience in reducing the incidence of cervical cancer in Shenyang.