研究表明，肿瘤的侵袭和转移不仅与肿瘤自身的特性有关，还与肿瘤的微环境关系密切。肿瘤相关巨噬细胞（ Tumor associated macrophage ，TAM）是肿瘤微环境中数量较多的炎性细胞，在不同的信号刺激下巨噬细胞分化成经典型的M1型巨噬细胞或替代激活型的M2型巨噬细胞。在许多恶性肿瘤中，不少研究证实，M2型巨噬细胞参与了肿瘤的侵袭和转移，胃癌的研究得出相似结论。 TAM的促肿瘤作用可能存在凝血因子的参与。缺氧环境亦可能在这一过程中起到重要作用。研究发现，胃癌中TAM的功能随位置的不同而变化，与细胞分化、胃癌分型无关。本文就TAM在胃癌中的研究现状做一综述，以期全面了解TAM在胃癌中的相互作用，为进一步深入研究二者的关系提供线索。%It has been confirmed that tumor invasion and metastasis is not only dependent on the charac -teristics of the tumor ,but also dependent on the tumor microenvironment .Tumor-associated macrophage ( TAM) , which constitutes a large number of the tumor -infiltrating immune cells,is stimulated into M1 macrophage and M2 macrophage by different signals in the tumor microenvironment .Whereas the vast majority of studies with nu-merous tumor types show that the presence of M 2 phenotypes in the tumor microenvironment is associated with a worse prognosis ,most studies in gastric cancer also claim the same results .Hypoxia and coagulation factors may both contribute to it .It has identified that the function of TAM could be changed with their location of tumor ,but it has nothing to do with cell differentiation and cell type of gastric cancer .In this review,we summarize the differ-ent and controversial effects of TAM in gastric cancer .
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