NQO1高表达提示宫颈癌预后不良

摘要

Objective To investigate the clinicopathological significance of upregulated NQO 1 protein expression in uterine cervix carcinoma ( UCC) .Methods Immunohistochemical staining was performed on paraf-fin-embedded UCC specimens from 123 patients.Disease-free survival(DFS)and overall survival(OS)rates for all cervical UCC patients were calculated using the Kaplan -Meier method ,and univariate or multivariate analyses were performed using the Cox proportional hazards regression model .Results The NQO1 protein showed a main-ly cytoplasmic staining pattern in cervical cancer cells ,and the strongly positive rate of NQO 1 was significantly higher in UCC.High-level NQO1 was closely associated with poor differentiation ,late-stage,lymph node metas-tasis and high-risk for HPV infection.Additionally,high-level NQO1 was associated with lower DFS and OS rates .Furthermore ,Cox analysis revealed that NQO 1 expression emerged as a significant independent hazard factor for DFS rate in patients with UCC .Conclusion NQO1 overexpression might be an independent biomarker for prognostic evaluation of UCCs .%目的：探讨NQO1蛋白在宫颈癌中的表达及其临床意义。方法免疫组化检测NQO1蛋白在123例宫颈癌标本的表达并比较其与临床病理学参数的相关性，Kaplan－Meier分析NQO1表达对患者无病生存期（ DFS）和总生存期（ OS）的影响，Cox分析宫颈癌的预后风险因素。结果 NQO1蛋白在宫颈癌中呈胞浆染色，其表达率明显高于正常宫颈组织，且NQO1高表达率与肿瘤组织分化、临床分期、淋巴结转移和HPV感染明显相关；NQO1高表达患者的DFS和OS均明显低于低表达者；NQO1高表达是宫颈癌患者预后不良的独立风险因素。结论 NQO1高表达可能是评估宫颈癌预后不良的生物学指标。