77例药物性肝损害患者过敏原检测结果分析

摘要

Objective To discuss the allergic factors of drug-induced liver injury( DILI). Methods 77 cases with DILI were given test serum allergens, and 77 cases were compared with normal. Results The positive rate of serum allergens in 77 DILI was 84. 42% (65/77) ;There were no statistically significant differences between inhaled allergens and food allergen(P > 0. 05). The higher positive allergens were dust mites/powder mite,ordinary ragweed/from plants,crab/shrimp/lobster and beef/lamb. And normal serum specific allergen positive rate was only 18. 18 % ( 14/77 ) , there was statistically significant difference between DILI and normals ( P < 0.01). Conclusions DILI patients had higher allergens tested positive rate,it can help know about allergen situation through serum allergens detection, and there are some certain significance for patients to avoid or reduce exposure to the allergen.%目的 对药物性肝损害(drug induced liver injury,DILI)患者血清过敏原检测进行讨论分析.方法 选择77例临床诊断为DILI的住院患者进行血清过敏原检测,并与77例正常人进行对照.结果 77例患者血清过敏原检测阳性率84.42%(65/77);吸入性过敏原与食入性过敏原阳性率比较差异无统计学意义(P ＞ 0.05).阳性率较高的为尘螨/粉螨、普通豚草/蒿属植物、蟹/虾/龙虾、牛肉/羊肉.而正常人血清特异性过敏原阳性率为18.18%(14/77),差异有统计学意义(P ＜ 0.01).结论 DILI患者具有较高的过敏原检测阳性率,过敏原检测可以了解DILI患者的过敏原状况,对指导患者避免或减少接触过敏原具有一定的意义.