Objective To compare the difference in clinical effect between combined therapy of atosiban and ritodrine and sin -gle drug therapy for premature .Methods We randomly divided 120 patients with preterm labor patients into A ,B and C groups ,40 in each group .The group A was treated with atosiban single drug therapy .The group B was treated with ritodrine single drug therapy .The group C was treated with combined therapy of ritodrine and atosiban .The differences in clinical effect ,heart function reserve and neo-natal outcome were compared among the three groups .Results In the group C,efficiency in 48 h and 7d,delivery gestational weeks and delivery sustain duration were significantly better than those in another two groups (P <0.05).After treatment,none of the three groups had serious adverse reactions .There were no significant difference in cardiac function between the group B and C patients ,but the difference was statistically significant when compared to the group A (P<0.05).The neonatal weight was significantly higher and asphyxia rate was significantly lower in the group C than those in another two groups were ( P<0.05 ) .Conclusion The combined therapy of ritodrine and atosiban is better than single drug therapy .It is safe and reliable .%目的 比较阿托西班与利托君联合用药与单一用药治疗早产的临床效果差异.方法 将120例先兆早产患者按照随机数字表法分为A、B、C三组各40例.A组患者给予阿托西班单药治疗,B组给予利托君单药治疗.C组给予阿托西班与利托君联合用药,比较三组患者的临床效果、心脏储备功能及新生儿结局差异.结果 C组患者48 h、7 d有效率、分娩时孕周以及分娩维持时间与其他两组比较差异有统计学意义(P<0.05).治疗后,三组均未发生严重不良反应,B、C两组患者心脏功能差异无统计学意义,但与A组比较差异有统计学意义(P<0.05).C组患者新生儿体重显著高于其他两组,且窒息率显著低于其他两组(P<0.05).结论 阿托西班与利托君联合用药疗效优于单独用药且安全可靠.
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