影响维持性透析慢性肾功能衰竭患者生活质量的相关因素分析

摘要

Objective To investigate the related factors influencing the quality of life of patients with chronic renal failure un -dergoing maintenance dialysis.Methods A total of 136 patients (dialysis group) undergoing maintenance hemodialysis in our hospital from February 2014 to February 2016,and 150 healthy subjects (control group) who received physical examination in our hospital in the same period were enrolled in the study .The Kidney Disease Quality of Life Short Form 1.3 (KDQOL-SFTM1.3) scale was used to assess the quality of life of patients .The clinical data such as age,gender,economic status,educational level,marital status,dialysis time,dialysis frequency and primary disease were collected .The hemoglobin,albumin,urea clearance index (Kt/V) and other laborato-ry indexes were detected and calculated .Results The total score of general health -related quality of life (SF-36) in the dialysis group was significantly lower than that in the control group (P <0.05).There were statistically significant differences in the total score of SF -36 and KDTA score among patients with different ages ,economic status,educational levels,marital status,duration of dialysis,dialysis frequencies,levels of hemoglobin and albumin or Kt /V (P <0.05).Logistic regression analysis showed that age ,economic status,edu-cational level,marital status,duration of dialysis,dialysis frequency,hemoglobin,albumin and Kt /V were influencing factors of scores of SF-36 and KDTA in these patients.Conclusion The quality of life of patients undergoing maintenance dialysis is significantly lower than that of healthy people .Age,economic status,educational level,marital status,dialysis time,dialysis frequency,hemoglobin,albumin and Kt /V are important factors that affect the quality of life of these patients .%目的 探讨维持性透析慢性肾功能衰竭患者生活质量的相关因素.方法 选取我院2014年2月至2016年2月136例维持性透析患者(透析组),选取同期在我院体检的健康人群150例(对照组),采用肾脏疾病生活质量简表(KDQOL-SFTM1.3)量表评估患者生活质量.收集患者年龄、性别、经济状况、文化程度、婚姻状况、透析时间、透析频率、原发病等临床资料,检测并计算患者血红蛋白、白蛋白、尿素清除指数(Kt/V)等实验室指标.结果 透析组一般健康相关生存质量(SF-36)总分显著低于对照组(P<0.05).不同年龄、经济状况、文化程度、婚姻状况、透析时间、透析频率、血红蛋白、白蛋白、Kt/V水平患者SF-36总分、KDTA总分比较差异有统计学意义(P<0.05).Logistic回归分析结果显示,年龄、经济状况、文化程度、婚姻状况、透析时间、透析频率、血红蛋白、白蛋白、Kt/V是维持性透析患者SF-36和KDTA评分的影响因素.结论 维持性透析患者生活质量与健康人群相比显著降低.年龄、经济状况、文化程度、婚姻状况、透析时间、透析频率、血红蛋白、白蛋白、Kt/V均为影响维持性透析慢性肾功能衰竭患者生活质量的重要因素.