Objective To observe the changes of serum levels of PCT and hs-CRP of patients with coronary heart disease,to analyze their correlations with coronary artery plaques. Methods A total of 200 patients with coronary heart disease were selected in the People′s Hospital of Meizhou from February 2012 to August 2015,and they were divided into A group (diagnosed as stable angina pectoris,n = 121) and B group( diagnosed as acute coronary syndrome,n = 79) according to coronary angiography results. Virtual histology intravascular ultrasound was used to examine the coronary artery plaques related index,including plaque area,plaque area stenosis ratio,mean diameter of blood vessel,mean diameter of lumen,vascular remodeling index,eccen - tric index,plaque burden,necrotic core area,calcification core area,fibro - fatty area. Laboratory examination results and coronary artery plaques related index were compared between the two groups,correlations between serum level of PCT,of hs-CRP and coronary artery plaques related index was respectively analyzed. Results No statistically significant differences of fasting blood glucose,serum level of TC,LDL-C or HDL-C was found between the two groups(P ﹥0. 05);serum levels of PCT and hs-CRP of B group were statistically significantly higher than those of A group(P < 0. 05). No statistically significant differences of plaque area,plaque area stenosis ratio,mean diameter of blood vessel,mean diameter of lumen,plaque burden or calcification core area was found between the two groups( P ﹥ 0. 05),while vascular remodeling index,eccen - tric index,necrotic core area and fibro - fatty area of B group were statistically significantly higher than those of A group( P < 0. 05). Pearson correlation analysis showed that,serum PCT level of patients with coronary heart disease was positively correlated with vascular remodeling index( r = 0. 612),eccen - tric index( r = 0. 658),necrotic core area( r =0. 688),respectively,was negatively correlated with fibro - fatty area( r = - 0. 695,P < 0. 05);serum hs-CRP level of patients with coronary heart disease was positively correlated with vascular remodeling index(r = 0. 456),eccen - tric index(r= 0. 724),necrotic core area(r = 0. 487),respectively,was negatively correlated with fibro - fatty area(r = - 0. 616,P <0. 05). Conclusion Compared with patients with stable angina pectoris,serum levels of PCT and hs-CRP of patients with acute coronary syndrome are significantly elevated,while vascular remodeling index,eccen - tric index,necrotic core area and fibro -fatty area are significantly accrescent,serum levels of PCT and hs-CRP have certain correlations with the formation of coronary artery plaques.%目的：观察冠心病患者血清降钙素原（PCT）、超敏 C 反应蛋白（hs-CRP）水平变化，探讨其与冠状动脉斑块的相关性。方法选取2012年2月—2015年8月梅州市人民医院收治的冠心病患者200例，根据冠状动脉造影结果将患者分为稳定型心绞痛（SAP）组121例和急性冠脉综合征（ACS）组79例。采用虚拟组织学血管内超声（VH-IVUS）检查斑块面积、面积狭窄率、血管平均径、管腔平均径、血管重塑指数、斑块偏心指数、斑块负荷、坏死核心（NC）面积、钙化部分（DC）面积、纤维脂质成分（FF）面积等冠状动脉斑块指标。比较两组患者实验室检查指标、冠状动脉斑块指标，并分析冠心病患者血清 PCT、hs-CRP水平与冠状动脉斑块指标的相关性。结果两组患者空腹血糖及血清总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）水平比较，差异无统计学意义（P ﹥0.05）；ACS 组患者血清 PCT、hs-CRP水平高于 SAP 组（P ＜0.05）。两组患者斑块面积、面积狭窄率、血管平均径、管腔平均径、斑块负荷、DC 面积比较，差异无统计学意义（P ﹥0.05）；ACS 组患者血管重塑指数、斑块偏心指数、NC 面积、FF 面积大于 SAP 组（P ＜0.05）。Pearson 相关性分析结果显示，冠心病患者血清 PCT 水平与血管重塑指数（r ＝0.612）、斑块偏心指数（r ＝0.658）、NC 面积（r ＝0.688）呈正相关，与 FF 面积（r ＝-0.695）呈负相关（P ＜0.05）；血清hs-CRP水平与血管重塑指数（ r ＝0.456）、斑块偏心指数（ r ＝0.724）、NC 面积（ r ＝0.487）呈正相关，与 FF 面积（r ＝-0.616）呈负相关（ P ＜0.05）。结论与 SAP 患者相比，ACS 患者血清 PCT、hs-CRP水平升高，血管重塑指数、斑块偏心指数、NC 面积、FF 面积增大，且冠心病患者血清 PCT、hs-CRP水平与冠状动脉斑块形成有一定相关性。
展开▼
