结核分枝杆菌异质性耐药诊断方法的研究进展

摘要

结核病是严重威胁人类健康的慢性传染病之一.近年来结核病耐药现象较为严重,且耐药结核病发病率不断升高,已成为结核病防治工作的难点.异质性耐药是一种特殊的耐药现象,可导致耐多药、多耐药、全耐药菌株出现,故早期诊断并制定有效的抗结核方案对结核病防控工作具有重要临床意义.本文综述了结核分枝杆菌异质性耐药诊断方法的研究进展,以期为临床早期诊断耐药结核病提供参考.%Tuberculosis (TB) is one of chronic infectious diseases that seriously threating the human health. In recent years,drug resistant tuberculosis became one of clinical questions with the morbidity increased year by year. Heteroresistance is a special drug resistance type,may lead to multi-drug resistant and extensive drug resistant mycobacterium tuberculosis,so it is with great clinical significance to early diagnose TB and make effective anti-TB programmes in the prevention and control of TB.This paper reviewed the progress on diagnostic methods of heteroresistance in mycobacterium tuberculosis,to provide a reference for early diagnosis of drug resistant TB on clinic.