胰岛素样生长因子结合蛋白-2与胰腺癌临床病理因素及诊疗价值分析

摘要

目的 研究和分析胰岛素样生长因子结合蛋白-2与胰腺癌的临床病理因素及诊疗价值.方法 选取胰腺癌患者130例, 分析130例患者的临床病例资料, 实验研究对象分为3个组:胰腺癌组、胰腺良性病变组和正常胰腺组.检测标本中胰岛素样生长因子结合蛋白-2基因mRNA的相对表达量, 观察统计胰岛素样生长因子结合蛋白-2的阳性表达情况, 及其与胰腺癌临床病理因素的关系.结果 胰岛素样生长因子结合蛋白-2 mRNA基因的相对表达量在胰腺正常组中为 (1.00±0.07), 在胰腺良性肿瘤组中为 (2.10±0.17), 在胰腺癌组中为 (4.17±0.17) .胰腺癌组中胰岛素样生长因子结合蛋白-2 mRNA基因的相对表达量较胰腺良性肿瘤组及正常胰腺组高, 差异有统计学意义 (P＜0.05);胰腺良性肿瘤组中胰岛素样生长因子结合蛋白-2 mRNA基因的相对表达量较正常胰腺组高, 差异有统计学意义 (P＜0.05);在胰腺组织的胞质中胰岛素样生长因子结合蛋白-2的表达相对较多, 胰腺癌组织中的阳性表达率较胰腺癌旁组织高, 并在正常胰腺组中几乎不表达, 差异有统计学意义 (P＜0.05);胰岛素样生长因子结合蛋白-2与术前血清CA19-9的含量有关 (P＜0.05);通过相关性分析, 胰岛素样生长因子结合蛋白-2的阳性表达与肿瘤分化程度呈负相关趋势, 与淋巴结转移及肿瘤TNM分期呈正相关趋势 (P＜0.05) .结论 胰岛素样生长因子结合蛋白-2mRNA在胰腺癌组织中存在表达, 胰岛素样生长因子结合蛋白-2阳性表达越差, 肿瘤分化程度越高, TNM分期越晚.%ObjectiveTo study and analyze the clinical and pathological factors of insulin-like growth factor binding protein-2 and pancreatic cancer.Methods 130 patients with pancreatic cancer were selected and the clinical data of 130 patients were analyzed.The experimental subjects were divided into three groups:pancreatic cancer group, benign pancreatic lesion group and normal pancreas group.The relative expression of insulin-like growth factor binding protein-2 gene mRNA was detected in the specimens.The positive expression of insulin-like growth factor binding protein-2 was observed and its relationship with clinicopathological factors of pancreatic cancer.Results 1 The relative expression level of the insulin-like growth factor binding protein-2 mRNA gene was found to be (1.00±0.07) in the normal pancreatic group, (2.10±0.17) in the pancreatic benign tumor group, and (4.17±0.17) in the pancreatic cancer group.The relative expression of insulin-like growth factor binding protein-2mRNA gene in pancreatic cancer group was higher than that in benign pancreatic tumor group and normal pancreas group (P＜0.05).Insulin-like growth factor binding in benign pancreatic tumor group The relative expression of protein-2 mRNA was higher than that of normal pancreas (P＜0.05).2The expression of insulin-like growth factor binding protein-2 was more abundant in the cytoplasm of pancreatic tissue.Pancreatic cancer The positive expression rate in tissues was higher than that in pancreatic cancer tissues, and was not expressed in normal pancreas group, the difference was statistically significant (P＜0.05);3 insulin-like growth factor binding protein-2 and preoperative serum CA19-9 The difference was statistically significant (P＜0.05).By correlation analysis, the positive expression of insulin-like growth factor binding protein-2 was negatively correlated with the degree of tumor differentiation, and positively correlated with lymph node metastasis and tumor TNM staging. (P＜0.05).Conclusion Insulin-like growth factor binding protein-2 mRNA is expressed in pancreatic cancer tissues.The positive expression of insulin-like growth factor binding protein-2 is worse, the higher the degree of tumor differentiation, the later the TNM stage.