血清肿瘤标志物单项及联合检测在肺癌诊断中的临床价值

摘要

目的 探讨血清癌胚抗原(Carcinoembryonic antigen,CEA)、糖类抗原19-9(CA19-9)、糖类抗原125(CA125)、细胞角蛋白19片断(Cytokeratinfragment 19,CYFRA21-1)、神经特异性烯醇化酶(Neuron-specific enolase,NSE)、鳞状细胞抗原(SCC-Ag)6种肿瘤标志物单项及联合检测在肺癌诊断中的临床价值.方法 采用化学发光免疫法检测92例肺癌患者、92例肺良性疾病患者、92例健康体检者的血清CEA、CA19-9、CA125、CYFRA21-1、NSE、SCC-Ag表达水平.结果 肺癌患者的血清肿瘤标志物CEA、CA19-9、CA125、CYFRA21-1、NSE、SCC-Ag的表达均明显高于肺良性疾病患者和健康体检者(P均<0.05);6种肿瘤标志物对肺癌诊断的灵敏性和准确度分别为:CEA(51.1%、73.3%)、CYFRA21-1(58.7%、73.9%)、CA125(38.0%、71.4%))、CA19-9(27.2%、70.3%)、NSE(26.1%、65.9%)、SCC-Ag(35.9%、71.0%),而六者联合检测的灵敏性和准确度分别为92.4%和83.7%,明显高于各单项检测(P＜0.05).结论 血清肿瘤标志物CEA、CA19-9、CA125、CYFRA21-1、NSE、SCC-Ag是诊断肺癌较好的标志物,六者联合检测可明显提高肺癌诊断的灵敏性和准确度.%Objective To investigate the Clinical values in lung cancer diagnosis to combine six serum tumor markers CEA,CYFRA21-l,NSE,SCC-Ag,CA19-9and CA125. Methods To analyze retrospectively the diagnosis sensititivity and specificity of CEA,CYFRA21-l,NSE,SCC-Ag,CA19-9 and CA125 in 92 lung cancer patients, 92 benign lung disease and 92 health a-dults. Results The serum tumor marker levels in the lung cancer group were obviously higher than those in health adults group and benign lung disease group ( P <0. 05 );These six serum tumors combinations may be more sensitive and helpful in the diagnosis of lung cancer. Conclusion Combination of multiple tumor markers can increase the clinical diagnosisvalue in lung cancer.