妇科门诊育龄妇女 HPV感染与宫颈癌筛查情况分析

摘要

Objective To explore the human papillomavirus ( HPV) infection in gynecological clinic fertile women and the cervical cancer screening status .Methods 300 cases of fertile women were selected as research subjects .HPV infection and its value in evaluation of cervical cancer and precancerous lesion screening were studied .Results HPV infection rate was 29.7%(89 cases);112 times of infection occurred in 300 cases;HPV16,HPV52 and HPV58 were the most common subtypes with constituent ratio of 20.5%(23 cases),10.7%(12 cases)and 8.9%(10 cases);Single infection rate and multiple infection rate were 28.0%(84 cases)and 9.3%(28 cases)respectively.Compared with HPV-negative patients,the occurrence of CIN1, CIN2,CIN3 and squamous carcinoma in HPV-positive patients increased significantly (P<0.05).Conclusion HPV infection rate is high in gynecological clinic fertile women ,and HPV16,HPV52 and HPV58 are the most common subtypes .HPV is the ide-al indicator for cervical cancer and precancerous lesion screening .%目的：探讨妇科门诊育龄妇女人乳头瘤病毒（ HPV）的感染情况及HPV在宫颈癌筛查中的作用。方法选择门诊就诊的300例育龄妇女为研究对象，检测HPV感染情况及评估HPV在宫颈癌及其癌前病变筛查中的作用。结果300例妇女HPV感染率为29．7％（89例），共有112人次感染。 HPV16型、HPV52型及HPV58型是HPV感染的最常见亚型，构成比分别为20．5％（23例）、10．7％（12例）和8．9％（10例）；单一感染率为28．0％（84例），多重亚型感染率为9．3％（28例）。与HPV阴性者相比，HPV阳性者CIN1、CIN2、CIN3及鳞癌发生率显著升高（P＜0．05）。结论妇科门诊育龄妇女HPV感染率高，HPV16型、HPV52型及HPV58型是最常见的亚型。 HPV是筛查宫颈癌及其癌前病变的理想指标。