卵巢癌患者血清 HE4 水平与病理分型的相关性

摘要

Objective To observe and analyze the correlation between the level of HE 4 and pathological classification of ovarian cancer.Methods According to biopsy results,164 cases was divided into 3 groups.A group had ovarian cancer (52 ca-ses),B group had benign ovarian lesions (57 cases),and,C group were healthy women (55 cases).The serum HE4 and CA125 concentrations of all cases were detected by chemiluminescence immunoassay.The sensitivity ,specificity and pathological classifi-cation were analyzed.Results Compared with C group,The level of HE4 and CA125 of A group and CA125 of B group had sig-nificant difference(P<0.01).HE4 had higher coincidence rate,sensitivity and specificity than CA125 (P<0.01).Serum HE4 amounts of 4 types of ovarian cancer were varied.There were significant differences (P<0.05).Conclusion HE4 is highly ex-pressed in ovarian cancer patients and has good coincidence rate with pathological results.The sensitivity and specificity of HE 4 are high and has a certain relevance with pathological classification which has great value in early diagnosis ,differential diagnosis and identification of types.%目的 探讨卵巢癌患者血清附睾蛋白4( HE4)水平与病理分型的相关性. 方法 选取164例妇女为研究对象,进行病理切片后,将确诊为卵巢癌的患者设为A组(52例),卵巢良性病变患者设为B组(57例),卵巢健康妇女设为C组(55 例). 应用化学免疫发光法检测所有研究对象的血清HE4 浓度及CA125含量,分析其特异性、敏感性及与病理分型的关系. 结果 与C组比较,除B组血清HE4水平有显著性差异( P<0.05)外,A组HE4、CA125 及B组CA125水平均有极显著性差异(P<0.01). 血清HE4指标用于诊断卵巢癌的符合率、特异性与敏感性均显著高于CA125指标(P<0.01). 4种类型卵巢癌平均血清HE4含量各不相同,差异具有统计学意义(P<0.05). 结论 HE4在卵巢癌患者中具有较高的表达率,与病理结果符合率较高,且特异性与敏感性亦较高,与病理分型具有一定关联性,在早期诊断、鉴别诊断与分型中具有重要价值.