微创介入疗法对肝癌患者 T细胞免疫功能的影响分析

摘要

目的：比较肝动脉栓塞化疗（ TACE）和射频消融（ RFA）治疗肝癌患者的T细胞免疫功能变化。方法将90例肝癌患者随机分为TACE组和RFA组，检测患者血清中的AST和ALT水平变化，比较患者的CD3＋， CD4＋， CD8＋和CD4＋／CD8＋水平；比较不同直径的肿瘤患者治疗前后的CD4＋／CD8＋水平。结果患者治疗过程中AST水平均无明显变化（P＞0．05），2组患者不同时间的AST水平无统计学差异（P＞0．05）。患者手术后第1天的ALT水平较治疗前明显增加（P＜0．05），术后第7天与治疗前无明显差异（P＞0．05）。2组患者术后第1天的ALT水平具有统计学差异（P＜0．05）。不同大小的肿瘤患者不同时间的CD4＋／CD8＋水平无统计学差异（P＞0．05）。2组患者术后第7天的CD3＋，CD4＋和CD4＋／CD8＋具有统计学差异（P＜0．05），而CD8＋无统计学差异（P＞0．05）。结论 RFA对肝癌患者的T细胞免疫功能有促进作用，而TACE则会抑制患者的T免疫功能。%Objective To compare the T-cell immune function change of liver cancer patients treated with transcatheter arterial chemoembolization ( TACE) and radiofrequency ablation ( RFA) .Methods 90 cases of liver cancer were randomly di-vided into TACE group and RFA group,The change of serum AST and ALT levels were detected,and levels of CD3+,CD4+, CD8+and CD4+/CD8+were compared.The levels of CD4+/CD8+in tumors of different diameters before and after treat-ment were also compared.Results AST level in patient had no significant changes (P>0.05),levels of AST at different peri-ods of the 2 groups showed no significant difference (P>0.05).ALT level of patients 1 d after operation significantly increased than before treatment (P<0.05),but ALT level of patients 7 d after operation and before treatment(P>0.05)had no significant difference;ALT level 1 d after operation in the 2 groups had statistical differences (P<0.05).CD4+/CD8+levels in tumors of different sizes had no significant difference at different periods (P>0.05).CD3+,CD4+and CD4+/CD8+7 d after opera-tion in the 2 groups showed significant difference (P<0.05),but CD8+levels had no significant difference (P>0.05).Con-clusion RFA has positive effect on T-cell immune function in patients with hepatocellular carcinoma yet TACE can inhibit T-cell immune function.