小细胞肺癌的临床病理特征及性别差异表现

摘要

Objective To investigate the clinical and pathological features of small cell lung cancer and gender differ-ences.Methods Clinical data of 75 cases of small cell lung cancer were retrospectively analyzed.Results 62 were male and 13 female,mean age (64.6 ±11.2)years,the peak incidence of both gender were 60~69 years old,there was no significant differ-ence between the 2 groups (P>0.05).There had 48 cases of patients with history of smoking (64.0%),the percentage of male was higher than female,there was statistically significant difference (P<0.05).Incidence ratio between cities and towns was 2.17:1,mainly was LD,central type,there had no significant difference (P>0.05)between the 2 sexes.Initial symptoms includ-ed cough,sputum,fever,chest tightness,shortness of breath,chest pain,and pulmonary symptoms,there had significant difference (P<0.05)between the 2 sexes.Location of the lesion was mainly on the right upper lobe and the left upper lobe,male patients was mainly on the right upper lobe,and female patients was mainly on the right lower lobe,there had slight difference.Conclusion Small cell lung cancer is male-dominated in the pathogenesis,and smoking is one of the most important risk factor,the tumor is mainly in the right upper lobe.%目的：探讨小细胞肺癌的临床病理特点以及不同性别的差异表现。方法回顾性分析75例小细胞肺癌患者的临床病理资料。结果男性62例，女性13例，平均年龄（64．6±11．2）岁，两种性别的发病高峰期均为60～69岁，两者比较无统计学差异（P＞0．05）。有吸烟史48例（64．0％），男性所占比率明显高于女性，存在统计学意义（P＜0．05）。城市与乡镇发病比例为2．17∶1，主要以LD、中心型为主，不同性别间比较无统计学差异（P＞0．05）。首发症状包括咳嗽、咳痰、发热、胸闷气短、胸部疼痛以及肺外症状，不同性别间首发症状比较均存在统计学差异（P＜0．05）。病变位置于右肺上叶与左肺上叶最多，其中男性患者中以右肺上叶最为多见，女性患者为右肺下叶最为多见，略有差异。结论小细胞肺癌发病以男性为主，而吸烟史是该疾病的最主要危险因素之一，肿瘤多位于右肺上叶。