IL-2和IL-10在急性髓性白血病患儿血清中的水平及其临床意义

摘要

目的 观察急性髓性白血病患儿血清中白细胞介素(IL)-2和IL-10的水平及其临床意义.方法 纳入急性髓性白血病患儿80例,其中初发27例、缓解25例、复发28例.同期纳入体检健康者50例患儿为对照组.应用酶联免疫吸附法(Elisa)检测血清中IL-2和IL-10水平.结果 与对照组比较,急性髓性白血病患儿血清中IL-2水平显著降低,IL-10水平显著升高(P<0.01).血清中IL-2和IL-10水平与急性髓性白血病患儿的年龄、性别、骨髓中白血病细胞比例、FAB分型无显著相关性(P>0.05).急性髓性白血病初发和复发组患儿血清中IL-2和IL-10水平与缓解组比较,有统计学差异(P<0.01).急性髓性白血病初发与复发患儿血清中IL-2和IL-10水平比较,无统计学意义(P>0.05).结论 急性髓性白血病患儿血清中IL-2和IL-10水平变化明显,与该病的预后联系密切.%Objective To investigate serum levels of of IL-2 and IL-10 in patients with acute myeloid leukemia and the clinical significance. Methods 80 cases of acute myeloid leukemia were selected,including initial treatment group(27 cases), remission group(25 cases),and recurrent group(28 cases). 50 healthy cases was selected as the control group. Elisa method was used to measure serum levels of IL-2 and IL-10. Results Compared with the control group,serum level of IL-2 remarkably de-creased,while IL-10 was obviously increased(P<0. 01). Serum levels of IL-2 and IL-10 had no significant correlation with age, sex,proportion of bone marrow leukemia cells,and FAB types(P>0. 05). Serum levels of IL-2 and IL-10 in initial treatment group and recurrent group had sigmficant difference compared with remission group(P<0. 01). There was no statistical signifi-cance in serum levels of IL-2 and IL-10 between initial treatment group and recurrent group(P>0. 05). Conclusion Serum lev-els of IL-2 and IL-10 in patients with acute myeloid leukemia significantly changed,and is closely related to occurrence and devel-opment of acute myeloid leukemia.