IMMOBILIZATION OF POTENTIALLY BIOACTIVE MOIETIES ONTO POLYETHER WITH POLY(ETHYLENE GLYCOL)-SULFONATE SPACER

摘要

A new reactive graft copolymer, poly（tetramthylene glycol） - graft-w-propyl sodiumsulfonate-poly（ethylene glycol） （PTMG-g-PEG-CH2CH2CH2SO3-Na+）, was synthesizedby the cationic polymerization of a-w-bifunctional PEG macromonomer （O?CH2—PEG——CH2 CH2 CH2 SO3 Na） and THF. The obtained copolymer exhibits the expected structureas indicated by the result of characterization. Two amino acids （L-arginine, L-tyrosine）were covalently attached to the copolymer after converting the sulfonate group to sulfonylchloride. So the new reactive graft copolymer （PTMG-g-PEG-CH2CH2CH2SO3-Na+） isexpected to be very useful in attachment of potentially bioactive moieties to polymer viaa hydrophilic PEG spacer.