Synthesis of poly(ethylene glycol)-SS-poly(ε-caprolactone)-SS-poly(ethylene glycol)triblock copolymers via end-group conjugation and self-assembly for reductively responsive drug delivery

Junbo LI; Junting JIANG; Biyu ZHOU; Chaohuang NIU; Wendi WANG; Wenlan WU

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Synthesis of poly(ethylene glycol)-SS-poly(ε-caprolactone)-SS-poly(ethylene glycol)triblock copolymers via end-group conjugation and self-assembly for reductively responsive drug delivery

机译：端基共轭和自组装合成聚（乙二醇）-SS-聚（ε-己内酯）-SS-聚（乙二醇）三嵌段共聚物用于还原反应性药物递送

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机译：In this study,we describe a simple synthesis route to prepare triblock copolymers with disulfide-linkers,poly(ethylene glycol)-SS-poly(ε-caprolactone)-SS-poly(ethylene glycol)(PEG-SS-PCL-SS-PEG)for application in the reductively responsive release of doxorubicin(DOX).To synthesize PEG-SS-PCL-SS-PEG,two end-groups of PCL-diol were first modified with cystamine to introduce disulfide bonds and subsequently conjugated with PEG-NHS via carbodiimide chemistry.PEG-SS-PCL-SSPEG fabricated into polymeric micelles with stable structure and different nanoscale sizes via adjusting the PCL chain length,showing obvious reductive responsiveness and fast drug release of encapsulated DOX in the presence of glutathione(GSH).Moreover,DOX-loaded PEG-SS-PCL-SS-PEG micelles exhibited higher therapeutic efficacy than reduction-insensitive PEG-b-PCL micelles in vitro.Thus,end-groups conjugation is a simple and straightforward strategy to introduce intelligent responsiveness in biocompatible block copolymers and improve their therapeutic efficacy.

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来源
《材料科学前沿：英文版》 |2019年第4期|P.410-419|共10页
作者
Junbo LI; Junting JIANG; Biyu ZHOU; Chaohuang NIU; Wendi WANG; Wenlan WU;
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作者单位

School of Chemical Engineering and Pharmaceutics Henan University of Science and Technology Luoyang 471023 China;

School of Medicine Henan University of Science and Technology Luoyang 471023 China;

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收录信息中国科学引文数据库(CSCD);
原文格式 PDF
正文语种 chi
中图分类高分子化学（高聚物）;
关键词
poly-ε-caprolactone; poly(ethylene glycol); block copolymer; reductive responsiveness; drug; release;

机译：聚ε-己内酯;聚乙二醇）;嵌段共聚物还原反应性药品;释放;
入库时间 2024-01-27 03:53:21

Synthesis of poly(ethylene glycol)-SS-poly(ε-caprolactone)-SS-poly(ethylene glycol)triblock copolymers via end-group conjugation and self-assembly for reductively responsive drug delivery

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