8-羟基脱氧鸟苷作为DNA氧化损伤标志物在疾病诊断中的应用

摘要

In living cells, the excessive generation of reactive oxygen species can cause oxidative DNA lesions. Through DNA repair, 8 -hydroxydeoxyguanosine, an oxidative modified nucleoside of DNA, is excreted into the urine. Numerous studies have proved that the level of 8-hydroxydeoxyguanosine reflects not only the ratio of oxidative DNA damage and repair of modified DNA in human body, but also associates with the development of diabetes mellitus, carcinosis and cardiovascular disease. It might be a promising new biomarker of oxidative stress related diseases.%机体内,活性氧簇(reactive oxygen species,ROS)过度蓄积可造成DNA氧化损伤,产生8-羟基脱氧鸟苷(8-hydroxy-2’-deoxyguanosine,8-OHdG).多项研究表明,8-OHdG不仅反映整个机体平均的氧化损伤率及体内DNA氧化损伤与机体正常的修复作用,而且与糖尿病、癌症、心血管疾病的发生和病情发展有着密切的关系.本文对8-OHdG作为氧化损伤标志物在糖尿病及其并发症、癌症、心血管疾病的诊断及治疗评价中的应用进行了综述,认为8-OHdG可能成为氧化应激相关疾病的一种极有前途的生物标志物.