气相色谱法测定强力枇杷露中薄荷脑、磷酸可待因、吗啡、盐酸罂粟碱的含量

摘要

目的：建立气相色谱法同时测定强力枇杷露中薄荷脑、磷酸可待因、吗啡、盐酸罂粟碱四种成分含量的方法。方法：试样用乙酸乙酯振摇提取，色谱柱为100%二甲基聚硅氧烷固定液的毛细管柱，柱温从100℃程序升温至270℃，保持20 min，检测器为 FID。结果：薄荷脑、磷酸可待因、吗啡、盐酸罂粟碱在各自测定范围内有良好线性关系，各成分平均回收率（n=6）在96.76%~113.34%，RSD<6.0%。结论：本方法准确可靠，重现性好，可有效地控制强力枇杷露的质量。%Objective: To establish a GC method for the determination of menthol, codeine phosphate, morphine, papaverine hydrochloride in Qiangli Pipa syrup. Methods: The syrup was extracted by ethyl acetate and determined by gas chromatography with a flame ionization detector. The compounds were separated on an Agilent HP -1MS capillary column by using temperature programming. Results: The menthol, codeine phosphate, morphine, papaverine hydrochloride showed a good linear relationship, respectively, in their own detecting ranges. The average recoveries were between 96.76% and 113.34%,with RSD<6.0%. Conclusions: This method is accurate and suitable for the determination of menthol, codeine phosphate, morphine, papaverine hydrochloride in Qianli Pipa syrup.