急性心肌梗死患者应用质子泵抑制剂的利用评价及用药分析

摘要

Objective: To investigate the usage of proton pump inhibitors (PPIs) in patients with acute my-ocardial infarction, and to establish DUE criteria of PPIs. Methods: The usage of PPIs was analyzed with the data taken from the hospitalized cases with acute myocardial infarction from Jan. 2013 to Jun. 2014. Results: A total of 291 cases were enrolled. PPIs were used in 91.4% patients, and the average use dura-tion of each patients was (10.3 ±4.2) d. The main routes of administration were oral or intravenous-to-oral. Pantoprazole was the most used PPI through intravenous administration, with average dosage of (54.0±19.2) mg·d-1. Rabeprazole was the most used PPI through oral administration, with average dosage of (18.1±4.2) mg·d-1. Conclusion: PPIs were frequently used in long course of treatment. The choice of PPIs, dosage and administration were rational. Further efforts should be made on the dosage of administration and course of treatment.%目的：分析急性心肌梗死患者质子泵抑制剂（PPI）的使用情况，建立药物利用评价标准。方法：收集我院心血管内科2013年1月~2014年6月出院的急性心肌梗死患者的病例资料，对PPI的使用情况进行分析。结果：共纳入291例患者，PPI使用率91.4%，平均用药（10.3±4.2） d，给药方式口服、静脉继以口服为主，静脉途径多用泮托拉唑，平均剂量（54.0±19.2） mg·d-1，口服途径多用雷贝拉唑，平均剂量（18.1±4.2） mg·d-1。结论：我院心梗患者PPI使用率高、疗程较长，选药品种及用法用量基本合理；需加强对给药剂量和疗程的控制。