近年来,随着免疫抑制治疗、化疗、实体器官移植的增多,中心静脉置管术以及心脏人工瓣膜植入术等介入性治疗的开展,发生侵袭性真菌感染(invasive fungal infection,IFI)的患者人数逐年上升.三唑类抗真菌药物抗菌谱广、毒性较小、耐受性较好,用于治疗侵袭性真菌感染最为广泛.但由于其本身也作用于哺乳动物细胞色素P450酶系,易与其他药物发生相互作用产生毒性.本文对目前国内外已广泛用于临床的三唑类药物及近年来研发的新型三唑类药物的作用及应用特点进行比较,并对相关研究进展进行综述.%With the development and clinical application of immunosuppressive therapy, chemotherapy, organ transplantation, percutaneous-inserted central venous catheter (PICC) and heart valve prothesis im-plantation, occurrence of invasive fungal infection (IFI) is increasing in recent years. Triazole antifungal a-gents are widely used in the treatment of IFI, with wide antimicrobial spectrum, less toxicity and better tolerance. Meanwhile, drug-drug interaction of triazole appears frequently for its inhibition on mammalian cytochrome P450 enzyme system. Therefore, development of new triazole antifungal agent with better effica-cy and less adverse drug reactions is attracting much attention. This review compares the characteristics of triazole antifungal agents commonly applied in clinic, and summarizes the recent advances in the clinical application of triazole antifungal agents in the treatment of invasive fungal infections.
展开▼
