不同皮肤射线防护剂对鼻咽癌调强放疗放射性皮炎的防护疗效及患者生活质量的影响

摘要

Objective:To investigate the protective effect of different skin radiation protective agents on radiation dermatitis in patients with nasopharyngeal carcinoma treated by intensity modulated radiotherapy and the impact on their quality of life .Methods:Randomly divide 210 cases of patients who suffered from nasopharyngeal carcinoma and were treated with radical intensity modulated radiotherapy in department of radiotherapy of the hospital dated from Janu-ary 2007to December 2009 into three groups:the routine control group included 69 cases and was treated with routined radiation therapy ;the camellia oil group included70 cases and was treated with conventional radiation therapy and camellia oil ;the Biafine group included 71cases and was treated with con-ventional radiation therapy and Biafine.The incidence of acute radiation dermatitis after radiotherapy was compared in three groups ,and the quality of life of patients in the three groups was evaluated by dermatology quality of life index(DLQI).Results:The incidence of radiation dermatitis in the camellia oil group and the Biafine group were lower than that in the control group at the 6th week after radiotherapy (P<0.05 ).The difference of severity of radiation dermatitis in the camellia oil group and the Biafine group has no statistical significance (P>0.05).Conclusion:Both camellia oil and Biafine can effectively reduce the incidence of radiation dermatitis in patients with nasopharyngeal carcinoma and improve patients ’ quality of life.The effect in both of the two drugs treated groups are better than that of the conventional group in the prevention of nasopharyngeal carcinoma intensity modulated radiotherapy dermatitis .%目的：探讨不同皮肤射线防护剂对鼻咽癌调强放疗放射性皮炎的防护疗效及对患者生活质量的影响。方法：将2007年1月～2009年12月我院放疗科收治的210例鼻咽癌根治性调强放疗患者随机分为3组：常规对照组69例，予以常规放疗防护；山茶油组70例，在常规放疗防护基础上加用山茶油；比亚芬组71例，在常规放疗防护基础上加用比亚芬。比较3组患者放疗后急性放射性皮炎发生情况，并采用皮肤病生活质量量表（ DLQI）评价3组患者生活质量差异。结果：山茶油组和比亚芬组患者在放疗后第6周放射性皮炎发生的严重程度均低于常规对照组（P ＜0．05），山茶油组和比亚芬组患者放射性皮炎严重程度比较差异无统计学意义（P＞0．05）。结论：山茶油和比亚芬均能有效降低鼻咽癌患者放射性皮炎发生率，提高患者生活质量，两种药物预防鼻咽癌调强放疗放射性皮炎的疗效均优于常规组。