每日短信提醒服药对精神分裂症患者复发的预防效果

摘要

目的 探讨每日短信提醒服药对出院后精神分裂症患者复发的预防作用.方法 将91例临床痊愈的精神分裂症患者随机分为干预组(43例)和对照组(48例),两组患者均接受抗精神病药物维持治疗并电话和门诊随访2年,干预组给予每日短信提醒督促服药干预.采用生存分析法比较两组患者的无复发生存时间,用Log-Rank检验比较两组患者的复发率.结果 干预组和对照组的2年复发率分别为35.8%(95%可信区间为20.1%～51.5%)和61.2%(95%可信区间为46.9%～75.5%),Log-Rank检验显示两组复发率差异具有统计学意义(χ2=4.30,P=0.039).结论 每日短信提醒服药能有效预防精神分裂症患者的复发.%Objective To explore the prophylactic effect of daily short message(DSM) reminder for schizophrenia recrudescence. Methods Ninety-one discharged patients with clinically cured schizophrenia were randomly assigned to intervention group(n = 43) and control group(n = 48). Both groups were given antipsychotic treatment and followed up by telephone and outpatient service. The intervention group was given DSM reminder for surpervising drug taking additionaly. Survival analysis and Log-Rank test were used to compare the relapse-free survival time and the recrudescence rate of the two groups respectively. Results The two year recrudescence rates (95 ％ confidence interval) for the intervention and the control group were 35.8 ％ (20.1 ％ - 51.5 ％) and 61.2 ％ (46.9 ％ - 75.5 ％), respectively. Log-Rank test showed their difference had statistical significance(x2 = 4.30, P = 0. 039). Conclusion DSM reminder can prevent schizophrenia recrudescence effectively.